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Table 2 Summary of Predictors of mortality in HIV-associated TB patients in Serowe/Palapye district Botswana 2013

From: Human immunodeficiency virus-associated tuberculosis care in Botswana: evidence from a real-world setting

Variables

Hazard ratio

(95% CI)

P

Adjusted HR

(95% CI)

P

Age group, year

 < 35

1

 35–59

0.89 (0.46–1.7)

0.722

1.5 (0.75–3)

0.245

 ≥ 60

3.15 (1.28–7.73)

0.012

4.8 (1.8–13)

0.002

 Male sex

1.22 (0.67–2.23)

0.513

 Unemployed

1.2 (0.59–2.42)

0.627

Smoker

2.53 (0.76–8.42)

0.130

0.66 (0.13–3.4)

0.619

 Body weight < 50 kg

2.1 (0.94–4.71)

0.072

1.8 (0.7–4.5)

0.205

 Smear positive PTB

0.5 (0.27–0.93)

0.028

 Extrapulmonary

1.12 (0.59–2.13)

0.739

 Previous TB

0.74 (0.27–2.01)

0.571

 Fever

1.58 (0.85–2.94)

0.153

 Productive cough

0.94 (0.46–1.92)

0.870

 Night sweats

0.55 (0.26–1.16)

0.116

 Loss of weight

2.33 (1.07–5.04)

0.032

 Duration of symptoms > 3 months

3.85 (0.47–31)

0.207

 No ART use during TB treatment

2.49 (1.31–4.73)

0.005

5.6 (2.9–11)

< 0.001

 ART naïve

1.2 (0.66–2.2)

0.569

 OI other than TB

7.76 (3.96–15.25)

< 0.001

8.5 (4–18.4)

< 0.001

 CD4 counts cells/μl at TB < 200

2.02 (1.01–4.04)

0.046

 Hemoglobin < 10 g/dl

2.4 (1.3–4.5)

0.007

2.44 (1.3–4.6)

0.029

 Major Side effect

4.84 (2–12.3)

0.001

5 (1.6–17)

0.007

 IRIS

1.1 (0.53–2.27)

0.808

 Diabetes mellitus

0.049 (0–2559)

0.586

  1. TB tuberculosis, ART antiretroviral therapy, IRIS immune reconstitution inflammatory syndrome, HR hazard ratio, CI Confidence Interval. Major side effect found were Hepatoxicity (8/9), and Stevens Johnson syndrome 1/9 OI: opportunistic infection, and ART use during TB treatment: time-updated variables