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Table 4 Main results of the meta-analysis of TGF-ß1 gene polymorphisms in populations following HWE

From: Association of TGF-ß1 polymorphisms and chronic hepatitis C infection: a Meta-analysis

SNPs   No.of study Gene model OR(95%CI) P Heterogeneity text Publication bias
P(Q-test) I2(%) Begg’s Egger’s
-509 Total (HWE) 5 TT vs. CC 1.507 (1.262–1.799) 0.000 0.115 49.4 1.000 0.400
    TC vs. CC 1.240 (1.117–1.377) 0.000 0.394 0.0 1.000 0.304
   TT + TC vs. CC 1.200 (1.113–1.295) 0.000 0.170 40.2 1.000 0.353
   TT vs. CC + TC 1.141 (0.935–0.393) 0.193 0.504 0.0 1.000 0.563
   T vs. C 1.374 (1.074–1.758) 0.011 0.022 65.0 0.806 0.403
Egyptian (HWE) 2 TT vs. CC 1.567 (1.284–1.912) 0.000 0.244 26.3 1.000
(CHC-healthy)   TC vs. CC 1.272 (1.128–1.434) 0.000 0.437 0.0 1.000
   TT + TC vs. CC 1.225 (1.124–1.336) 0.000 0.302 6.3 1.000
   TT vs. CC + TC 1.407 (1.120–1.768) 0.003 0.372 0.0 1.000
   T vs. C 1.270 (1.153–1.399) 0.000 0.223 32.7 1.000
Total (HWE) 4 TT vs. CC 1.462 (1.215–1.760) 0.000 0.075 61.4 1.000 0.411
(CHC-healthy)   TC vs. CC 1.230 (1.101–1.373) 0.000 0.246 28.7 1.000 0.355
   TT + TC vs. CC 1.189 (1.098–1.288) 0.000 0.102 56.2 1.000 0.384
   TT vs. CC + TC 1.323 (1.069–1.636) 0.010 0.212 35.5 1.000 0.427
   T vs. C 1.300 (0.991–1.707) 0.058 0.020 69.3 0.308 0.228
codon 25 Total (HWE) 10 CC vs. GG 0.701 (0.417–1.180) 0.182 0.735 0.0 1.000 0.987
    CG vs. GG 0.974 (0.550–1.724) 0.927 0.002 67.5 0.602 0.775
   CC + CG vs. GG 0.956 (0.543–1.683) 0.875 0.001 68.5 0.754 0.769
   CC vs. GG + CG 0.766 (0.443–1.325) 0.341 0.896 0.0 1.000 0.924
   C vs. G 0.973 (0.626–1.512) 0.902 0.007 60.6 0.371 0.708
Total (HWE) 8 CC vs. GG 0.696 (0.411–1.179) 0.178 0.596 0.0 0.806 0.913
(CHC-healthy)   CG vs. GG 0.853 (0.474–1.533) 0.594 0.007 64.2 0.711 0.722
   CC + CG vs. GG 0.843 (0.468–1.518) 0.569 0.004 66.2 0.902 0.736
   CC vs. GG + CG 0.769 (0.441–1.342) 0.356 0.803 0.0 0.806 0.886
   C vs. G 0.864 (0.516–1.444) 0.576 0.008 63.4 0.711 0.723
  1. A random effects model was used when P-value for heterogeneity test was < 0.1; otherwise, a fixed effects model was used, and values in bold were statistically significant at P < 0.05. –, no number
  2. CHC chronic hepatitis C, CI confidence interval, HWE Hardy–Weinberg equilibrium, OR odds ratio, SNP single-nucleotide polymorphism, P (Q-test), P-value of Q-test for heterogeneity test