Table 4 Main results of the meta-analysis of TGF-ß1 gene polymorphisms in populations following HWE
From: Association of TGF-ß1 polymorphisms and chronic hepatitis C infection: a Meta-analysis
SNPs | No.of study | Gene model | OR(95%CI) | P | Heterogeneity text | Publication bias | |||
|---|---|---|---|---|---|---|---|---|---|
P(Q-test) | I2(%) | Begg’s | Egger’s | ||||||
-509 | Total (HWE) | 5 | TT vs. CC | 1.507 (1.262–1.799) | 0.000 | 0.115 | 49.4 | 1.000 | 0.400 |
TC vs. CC | 1.240 (1.117–1.377) | 0.000 | 0.394 | 0.0 | 1.000 | 0.304 | |||
TT + TC vs. CC | 1.200 (1.113–1.295) | 0.000 | 0.170 | 40.2 | 1.000 | 0.353 | |||
TT vs. CC + TC | 1.141 (0.935–0.393) | 0.193 | 0.504 | 0.0 | 1.000 | 0.563 | |||
T vs. C | 1.374 (1.074–1.758) | 0.011 | 0.022 | 65.0 | 0.806 | 0.403 | |||
Egyptian (HWE) | 2 | TT vs. CC | 1.567 (1.284–1.912) | 0.000 | 0.244 | 26.3 | 1.000 | – | |
(CHC-healthy) | TC vs. CC | 1.272 (1.128–1.434) | 0.000 | 0.437 | 0.0 | 1.000 | – | ||
TT + TC vs. CC | 1.225 (1.124–1.336) | 0.000 | 0.302 | 6.3 | 1.000 | – | |||
TT vs. CC + TC | 1.407 (1.120–1.768) | 0.003 | 0.372 | 0.0 | 1.000 | – | |||
T vs. C | 1.270 (1.153–1.399) | 0.000 | 0.223 | 32.7 | 1.000 | – | |||
Total (HWE) | 4 | TT vs. CC | 1.462 (1.215–1.760) | 0.000 | 0.075 | 61.4 | 1.000 | 0.411 | |
(CHC-healthy) | TC vs. CC | 1.230 (1.101–1.373) | 0.000 | 0.246 | 28.7 | 1.000 | 0.355 | ||
TT + TC vs. CC | 1.189 (1.098–1.288) | 0.000 | 0.102 | 56.2 | 1.000 | 0.384 | |||
TT vs. CC + TC | 1.323 (1.069–1.636) | 0.010 | 0.212 | 35.5 | 1.000 | 0.427 | |||
T vs. C | 1.300 (0.991–1.707) | 0.058 | 0.020 | 69.3 | 0.308 | 0.228 | |||
codon 25 | Total (HWE) | 10 | CC vs. GG | 0.701 (0.417–1.180) | 0.182 | 0.735 | 0.0 | 1.000 | 0.987 |
CG vs. GG | 0.974 (0.550–1.724) | 0.927 | 0.002 | 67.5 | 0.602 | 0.775 | |||
CC + CG vs. GG | 0.956 (0.543–1.683) | 0.875 | 0.001 | 68.5 | 0.754 | 0.769 | |||
CC vs. GG + CG | 0.766 (0.443–1.325) | 0.341 | 0.896 | 0.0 | 1.000 | 0.924 | |||
C vs. G | 0.973 (0.626–1.512) | 0.902 | 0.007 | 60.6 | 0.371 | 0.708 | |||
Total (HWE) | 8 | CC vs. GG | 0.696 (0.411–1.179) | 0.178 | 0.596 | 0.0 | 0.806 | 0.913 | |
(CHC-healthy) | CG vs. GG | 0.853 (0.474–1.533) | 0.594 | 0.007 | 64.2 | 0.711 | 0.722 | ||
CC + CG vs. GG | 0.843 (0.468–1.518) | 0.569 | 0.004 | 66.2 | 0.902 | 0.736 | |||
CC vs. GG + CG | 0.769 (0.441–1.342) | 0.356 | 0.803 | 0.0 | 0.806 | 0.886 | |||
C vs. G | 0.864 (0.516–1.444) | 0.576 | 0.008 | 63.4 | 0.711 | 0.723 | |||