Table 3 Main results of the meta-analysis of TGF-ß1 gene polymorphisms with the susceptibility to CHC compared with HL population
From: Association of TGF-ß1 polymorphisms and chronic hepatitis C infection: a Meta-analysis
SNPs | No.of study | Gene model | OR(95%CI) | P | Heterogeneity text | Publication bias | |||
|---|---|---|---|---|---|---|---|---|---|
P(Q-test) | I2(%) | Begg’s | Egger’s | ||||||
-509 | Total | 6 | TT vs. CC | 1.946 (1.109–3.415) | 0.020 | 0.002 | 76.2 | 0.221 | 0.949 |
TC vs. CC | 1.878 (1.082–3.261) | 0.025 | 0.000 | 82.9 | 0.221 | 0.453 | |||
TT + TC vs. CC | 2.004 (1.138–3.528) | 0.016 | 0.000 | 86.4 | 0.221 | 0.566 | |||
TT vs. CC + TC | 1.282 (1.084–1.516) | 0.004 | 0.177 | 36.7 | 0.462 | 0.862 | |||
T vs. C | 1.460 (1.065–2.000) | 0.019 | 0.000 | 83.9 | 0.452 | 0.644 | |||
Egyptian | 3 | TT vs. CC | 3.060 (1.529–6.122) | 0.002 | 0.046 | 67.5 | 0.296 | 0.895 | |
TC vs. CC | 3.123 (1.339–7.284) | 0.008 | 0.002 | 84.2 | 0.296 | 0.080 | |||
TT + TC vs. CC | 3.363 (1.477–7.655) | 0.004 | 0.001 | 86.1 | 0.296 | 0.168 | |||
TT vs. CC + TC | 1.462 (1.169–1.829) | 0.001 | 0.260 | 25.8 | 0.296 | 0.981 | |||
T vs. C | 2.276 (1.295–4.001) | 0.004 | 0.000 | 87.0 | 0.296 | 0.247 | |||
Caucasian (Iran) | 2 | T vs. C | 1.007 (0.891–1.139) | 0.907 | 0.584 | 0.0 | 1.000 | – | |
codon 10 | Total | 8 | CC vs. TT | 1.009 (0.837–1.216) | 0.926 | 0.669 | 0.0 | 0.902 | 0.944 |
CT vs. TT | 0.953 (0.874–1.038) | 0.269 | 0.969 | 0.0 | 0.711 | 0.472 | |||
CC + CT vs. TT | 0.974 (0.911–1.041) | 0.437 | 0.972 | 0.0 | 1.000 | 0.701 | |||
CC vs. TT + CT | 1.078 (0.870–1.336) | 0.492 | 0.407 | 3.0 | 0.902 | 0.769 | |||
C vs. T | 0.995 (0.918–1.079) | 0.907 | 0.725 | 0.0 | 1.000 | 0.811 | |||
Asian | 2 | CC vs. TT | 1.074 (0.801–1.441) | 0.632 | 0.170 | 46.8 | 1.000 | – | |
CT vs. TT | 1.929 (0.804–1.073) | 0.318 | 0.935 | 0.0 | 1.000 | – | |||
CC + CT vs. TT | 0.973 (0.873–1.085) | 0.624 | 0.514 | 0.0 | 1.000 | – | |||
CC vs. TT + CT | 1.245 (0.886–1.748) | 0.206 | 0.107 | 61.5 | 1.000 | – | |||
C vs. T | 1.029 (0.903–1.174) | 0.666 | 0.138 | 54.5 | 1.000 | – | |||
Caucasian | 3 | CC vs. TT | 1.098 (0.786–1.534) | 0.585 | 0.882 | 0.0 | 0.296 | 0.296 | |
CT vs. TT | 0.987 (0.855–1.139) | 0.854 | 0.784 | 0.0 | 1.000 | 0.682 | |||
CC + CT vs. TT | 1.000 (0.892–1.122) | 0.995 | 0.859 | 0.0 | 1.000 | 0.661 | |||
CC vs. TT + CT | 1.114 (0.764–1.626) | 0.575 | 0.779 | 0.0 | 0.296 | 0.103 | |||
C vs. T | 1.022 (0.890–1.173) | 0.763 | 0.956 | 0.0 | 1.000 | 0.942 | |||
Mix (Brazilian) | 2 | CC vs. TT | 0.853 (0.587–1.241) | 0.406 | 0.370 | 0.0 | 1.000 | – | |
CT vs. TT | 0.904 (0.756–1.082) | 0.270 | 0.916 | 0.0 | 1.000 | – | |||
CC + CT vs. TT | 0.924 (0.806–1.058) | 0.253 | 0.851 | 0.0 | 1.000 | – | |||
CC vs. TT + CT | 0.912 (0.588–1.417) | 0.683 | 0.279 | 14.6 | 1.000 | – | |||
C vs. T | 0.921 (0.779–1.090) | 0.338 | 0.477 | 0.0 | 1.000 | – | |||
codon 25 | Total | 9 | CC vs. GG | 0.740 (0.450–1.219) | 0.237 | 0.702 | 0.0 | 0.452 | 0.908 |
CG vs. GG | 0.832 (0.501–1.383) | 0.479 | 0.012 | 59.2 | 0.754 | 0.693 | |||
CC + CG vs. GG | 0.835 (0.505–1.382) | 0.484 | 0.008 | 61.3 | 0.754 | 0.713 | |||
CC vs. GG + CG | 0.814 (0.482–1.373) | 0.440 | 0.869 | 0.0 | 0.707 | 0.872 | |||
C vs. G | 0.933 (0.612–1.422) | 0.747 | 0.010 | 58.7 | 0.371 | 0.634 | |||
Asian | 2 | CC vs. GG | 0.917 (0.530–1.588) | 0.758 | 0.714 | 0.0 | 1.000 | – | |
CG vs. GG | 0.896 (0.680–1.181) | 0.435 | 0.607 | 0.0 | 1.000 | – | |||
CC + CG vs. GG | 0.917 (0.732–1.148) | 0.449 | 0.737 | 0.0 | 1.000 | – | |||
CC vs. GG + CG | 0.951 (0.536–1.687) | 0.863 | 0.712 | 0.0 | 1.000 | – | |||
C vs. G | 0.923 (0.733–1.163) | 0.498 | 0.899 | 0.0 | 1.000 | – | |||
Caucasian | 4 | CC vs. GG | 0.208 (0.037–1.172) | 0.075 | 0.357 | 0.0 | 1.000 | – | |
CG vs. GG | 0.913 (0.599–1.391) | 0.672 | 0.111 | 50.2 | 0.734 | 0.500 | |||
CC + CG vs. GG | 0.878 (0.317–2.428) | 0.802 | 0.029 | 66.9 | 0.734 | 0.482 | |||
CC vs. GG + CG | 0.283 (0.047–1.722) | 0.171 | 0.545 | 0.0 | 1.000 | – | |||
C vs. G | 0.869 (0.329–2.300) | 0.778 | 0.028 | 66.9 | 0.734 | 0.518 | |||
Mix (Brazilian) | 2 | CC vs. GG | 0.890 (0.117–6.743) | 0.910 | 0.651 | 0.0 | 1.000 | – | |
CG vs. GG | 0.648 (0.101–4.170) | 0.648 | 0.014 | 83.6 | 1.000 | – | |||
CC + CG vs. GG | 0.691 (0.102–4.690) | 0.705 | 0.010 | 84.8 | 1.000 | – | |||
CC vs. GG + CG | 0.984 (0.126–7.706) | 0.988 | 0.762 | 0.0 | 1.000 | – | |||
C vs. G | 0.769 (0.129–4.591) | 0.774 | 0.012 | 84.0 | 1.000 | – | |||