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Table 3 Main results of the meta-analysis of TGF-ß1 gene polymorphisms with the susceptibility to CHC compared with HL population

From: Association of TGF-ß1 polymorphisms and chronic hepatitis C infection: a Meta-analysis

SNPs   No.of study Gene model OR(95%CI) P Heterogeneity text Publication bias
P(Q-test) I2(%) Begg’s Egger’s
-509 Total 6 TT vs. CC 1.946 (1.109–3.415) 0.020 0.002 76.2 0.221 0.949
    TC vs. CC 1.878 (1.082–3.261) 0.025 0.000 82.9 0.221 0.453
  TT + TC vs. CC 2.004 (1.138–3.528) 0.016 0.000 86.4 0.221 0.566
  TT vs. CC + TC 1.282 (1.084–1.516) 0.004 0.177 36.7 0.462 0.862
  T vs. C 1.460 (1.065–2.000) 0.019 0.000 83.9 0.452 0.644
Egyptian 3 TT vs. CC 3.060 (1.529–6.122) 0.002 0.046 67.5 0.296 0.895
   TC vs. CC 3.123 (1.339–7.284) 0.008 0.002 84.2 0.296 0.080
  TT + TC vs. CC 3.363 (1.477–7.655) 0.004 0.001 86.1 0.296 0.168
  TT vs. CC + TC 1.462 (1.169–1.829) 0.001 0.260 25.8 0.296 0.981
  T vs. C 2.276 (1.295–4.001) 0.004 0.000 87.0 0.296 0.247
Caucasian (Iran) 2 T vs. C 1.007 (0.891–1.139) 0.907 0.584 0.0 1.000
codon 10 Total 8 CC vs. TT 1.009 (0.837–1.216) 0.926 0.669 0.0 0.902 0.944
    CT vs. TT 0.953 (0.874–1.038) 0.269 0.969 0.0 0.711 0.472
  CC + CT vs. TT 0.974 (0.911–1.041) 0.437 0.972 0.0 1.000 0.701
  CC vs. TT + CT 1.078 (0.870–1.336) 0.492 0.407 3.0 0.902 0.769
  C vs. T 0.995 (0.918–1.079) 0.907 0.725 0.0 1.000 0.811
Asian 2 CC vs. TT 1.074 (0.801–1.441) 0.632 0.170 46.8 1.000
   CT vs. TT 1.929 (0.804–1.073) 0.318 0.935 0.0 1.000
  CC + CT vs. TT 0.973 (0.873–1.085) 0.624 0.514 0.0 1.000
  CC vs. TT + CT 1.245 (0.886–1.748) 0.206 0.107 61.5 1.000
  C vs. T 1.029 (0.903–1.174) 0.666 0.138 54.5 1.000
Caucasian 3 CC vs. TT 1.098 (0.786–1.534) 0.585 0.882 0.0 0.296 0.296
   CT vs. TT 0.987 (0.855–1.139) 0.854 0.784 0.0 1.000 0.682
  CC + CT vs. TT 1.000 (0.892–1.122) 0.995 0.859 0.0 1.000 0.661
  CC vs. TT + CT 1.114 (0.764–1.626) 0.575 0.779 0.0 0.296 0.103
  C vs. T 1.022 (0.890–1.173) 0.763 0.956 0.0 1.000 0.942
Mix (Brazilian) 2 CC vs. TT 0.853 (0.587–1.241) 0.406 0.370 0.0 1.000
   CT vs. TT 0.904 (0.756–1.082) 0.270 0.916 0.0 1.000
  CC + CT vs. TT 0.924 (0.806–1.058) 0.253 0.851 0.0 1.000
  CC vs. TT + CT 0.912 (0.588–1.417) 0.683 0.279 14.6 1.000
  C vs. T 0.921 (0.779–1.090) 0.338 0.477 0.0 1.000
codon 25 Total 9 CC vs. GG 0.740 (0.450–1.219) 0.237 0.702 0.0 0.452 0.908
    CG vs. GG 0.832 (0.501–1.383) 0.479 0.012 59.2 0.754 0.693
  CC + CG vs. GG 0.835 (0.505–1.382) 0.484 0.008 61.3 0.754 0.713
  CC vs. GG + CG 0.814 (0.482–1.373) 0.440 0.869 0.0 0.707 0.872
  C vs. G 0.933 (0.612–1.422) 0.747 0.010 58.7 0.371 0.634
Asian 2 CC vs. GG 0.917 (0.530–1.588) 0.758 0.714 0.0 1.000
   CG vs. GG 0.896 (0.680–1.181) 0.435 0.607 0.0 1.000
  CC + CG vs. GG 0.917 (0.732–1.148) 0.449 0.737 0.0 1.000
  CC vs. GG + CG 0.951 (0.536–1.687) 0.863 0.712 0.0 1.000
  C vs. G 0.923 (0.733–1.163) 0.498 0.899 0.0 1.000
Caucasian 4 CC vs. GG 0.208 (0.037–1.172) 0.075 0.357 0.0 1.000
   CG vs. GG 0.913 (0.599–1.391) 0.672 0.111 50.2 0.734 0.500
  CC + CG vs. GG 0.878 (0.317–2.428) 0.802 0.029 66.9 0.734 0.482
  CC vs. GG + CG 0.283 (0.047–1.722) 0.171 0.545 0.0 1.000
  C vs. G 0.869 (0.329–2.300) 0.778 0.028 66.9 0.734 0.518
Mix (Brazilian) 2 CC vs. GG 0.890 (0.117–6.743) 0.910 0.651 0.0 1.000
   CG vs. GG 0.648 (0.101–4.170) 0.648 0.014 83.6 1.000
  CC + CG vs. GG 0.691 (0.102–4.690) 0.705 0.010 84.8 1.000
  CC vs. GG + CG 0.984 (0.126–7.706) 0.988 0.762 0.0 1.000
  C vs. G 0.769 (0.129–4.591) 0.774 0.012 84.0 1.000
  1. A random effects model was used when P-value for heterogeneity test was < 0.1; otherwise, a fixed effects model was used, and values in bold were statistically significant at P < 0.05
  2. CHC chronic hepatitis C; CI confidence interval, HL healthy, OR odds ratio, SNP single-nucleotide polymorphism; P (Q-test) P-value of Q-test for heterogeneity test