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Table 2 Main results of the meta-analysis of TGF-ß1 gene polymorphisms with the chronic HCV infection in total population

From: Association of TGF-ß1 polymorphisms and chronic hepatitis C infection: a Meta-analysis

SNPs   No.of study Gene model OR(95%CI) P Heterogeneity Publication
text bias
P(Q-test) I2(%) Begg’s Egger’s
-509 Total 7 TT vs. CC 2.081 (1.249–3.466) 0.005 0.002 73.0 0.133 0.897
    TC vs. CC 1.880 (1.162–3.044) 0.010 0.000 79.3 0.133 0.427
  TT + TC vs. CC 2.042 (1.240–3.361) 0.005 0.000 83.7 0.133 0.529
  TT vs. CC + TC 1.310 (1.114–1.542) 0.001 0.208 30.3 0.260 0.918
  T vs. C 1.503 (1.126–2.006) 0.006 0.000 81.8 0.230 0.580
Asian 2 TT vs. CC 1.242 (0.983–1.569) 0.070 0.108 61.2 1.000
   TC vs. CC 1.074 (0.939–1.227) 0.298 0.163 48.5 1.000
  TT + TC vs. CC 1.077 (0.976–1.190) 0.140 0.102 62.6 1.000
  TT vs. CC + TC 1.222 (0.942–1.585) 0.131 0.234 29.4 1.000
  T vs. C 1.375 (0.823–2.297) 0.223 0.041 76.1 1.000
Caucasian (Iran) 2 T vs. C 1.007 (0.891–1.139) 0.907 0.584 0.0 1.000
Egyptian 3 TT vs. CC 3.060 (1.529–6.122) 0.002 0.046 67.5 0.296 0.895
   TC vs. CC 3.123 (1.339–7.284) 0.008 0.002 84.2 0.296 0.080
  TT + TC vs. CC 3.363 (1.477–7.655) 0.004 0.001 86.1 0.296 0.168
  TT vs. CC + TC 1.462 (1.169–1.829) 0.001 0.260 25.8 0.296 0.981
  T vs. C 2.276 (1.295–4.001) 0.004 0.000 87.0 0.296 0.247
codon 10 Total 9 CC vs. TT 0.961 (0.802–1.151) 0.664 0.473 0.0 1.000 0.880
codon 25    CT vs. TT 0.961 (0.884–1.045) 0.350 0.975 0.0 0.917 0.301
  CC + CT vs. TT 0.972 (0.911–1.037) 0.390 0.987 0.0 0.917 0.726
  CC vs. TT + CT 1.011 (0.823–1.241) 0.917 0.179 30.0 0.917 0.676
  C vs. T 0.980 (0.907–1.060) 0.613 0.648 0.0 1.000 0.671
Asian 2 CC vs. TT 1.074 (0.801–1.441) 0.632 0.170 46.8 1.000
   CT vs. TT 1.929 (0.804–1.073) 0.318 0.935 0.0 1.000
  CC + CT vs. TT 0.973 (0.873–1.085) 0.624 0.514 0.0 1.000
  CC vs. TT + CT 1.245 (0.886–1.748) 0.206 0.107 61.5 1.000
  C vs. T 1.029 (0.903–1.174) 0.666 0.138 54.5 1.000
Caucasian 4 CC vs. TT 0.950 (0.703–1.284) 0.737 0.350 8.6 1.000 0.976
   CT vs. TT 1.000 (0.876–1.142) 1.000 0.891 0.0 0.734 0.818
  CC + CT vs. TT 0.991 (0.891–1.101) 0.859 0.930 0.0 1.000 0.448
  CC vs. TT + CT 0.934 (0.668–1.305) 0.689 0.220 32.1 1.000 0.861
  C vs. T 0.979 (0.865–1.109) 0.740 0.605 0.0 1.000 0.844
Mix (Brazilian) 2 CC vs. TT 0.853 (0.587–1.241) 0.406 0.370 0.0 1.000
   CT vs. TT 0.904 (0.756–1.082) 0.270 0.916 0.0 1.000
  CC + CT vs. TT 0.924 (0.806–1.058) 0.253 0.851 0.0 1.000
  CC vs. TT + CT 0.912 (0.588–1.417) 0.683 0.279 14.6 1.000
  C vs. T 0.921 (0.779–1.090) 0.338 0.477 0.0 1.000
Total 11 CC vs. GG 0.744 (0.455–1.218) 0.240 0.811 0.0 0.764 0.984
   CG vs. GG 0.940 (0.567–1.559) 0.811 0.003 63.7 0.592 0.748
  CC + CG vs. GG 0.935 (0.570–1.534) 0.790 0.003 64.6 0.592 0.740
  CC vs. GG + CG 0.809 (0.483–1.356) 0.421 0.931 0.0 0.548 0.879
  C vs. G 1.000 (0.670–1.494) 1.000 0.006 59.6 0.436 0.662
Asian 2 CC vs. GG 0.917 (0.530–1.588) 0.758 0.714 0.0 1.000
   CG vs. GG 0.896 (0.680–1.181) 0.435 0.607 0.0 1.000
  CC + CG vs. GG 0.917 (0.732–1.148) 0.449 0.737 0.0 1.000
  CC vs. GG + CG 0.951 (0.536–1.687) 0.863 0.712 0.0 1.000
  C vs. G 0.923 (0.733–1.163) 0.498 0.899 0.0 1.000
Caucasian 5 CC vs. GG 0.274 (0.063–1.190) 0.084 0.513 0.0 1.000 0.880
   CG vs. GG 1.215 (0.563–2.623) 0.620 0.042 59.7 0.806 0.333
  CC + CG vs. GG 1.130 (0.500–2.553) 0.769 0.023 64.8 0.806 0.349
  CC vs. GG + CG 0.339 (0.072–1.600) 0.172 0.767 0.0 1.000 0.882
  C vs. G 1.079 (0.518–2.247) 0.839 0.031 62.4 0.462 0.339
Mix (Brazilian) 2 CC vs. GG 0.890 (0.117–6.743) 0.910 0.651 0.0 1.000
   CG vs. GG 0.648 (0.101–4.170) 0.648 0.014 83.6 1.000
  CC + CG vs. GG 0.691 (0.102–4.690) 0.705 0.010 84.8 1.000
  CC vs. GG + CG 0.984 (0.126–7.706) 0.988 0.762 0.0 1.000
  C vs. G 0.769 (0.129–4.591) 0.774 0.012 84.0 1.000
Mix 3 C vs. G 1.038 (0.272–3.965) 0.956 0.003 83.3 1.000 0.205
  1. A random effects model was used when P-value for heterogeneity test was < 0.1; otherwise, a fixed effects model was used, and values in bold were statistically significant at P < 0.05. –, no number
  2. CI confidence interval, OR odds ratio, SNP single-nucleotide polymorphism, P (Q-test), P-value of Q-test for heterogeneity test