Table 2 Main results of the meta-analysis of TGF-ß1 gene polymorphisms with the chronic HCV infection in total population
From: Association of TGF-ß1 polymorphisms and chronic hepatitis C infection: a Meta-analysis
SNPs | No.of study | Gene model | OR(95%CI) | P | Heterogeneity | Publication | |||
|---|---|---|---|---|---|---|---|---|---|
text | bias | ||||||||
P(Q-test) | I2(%) | Begg’s | Egger’s | ||||||
-509 | Total | 7 | TT vs. CC | 2.081 (1.249–3.466) | 0.005 | 0.002 | 73.0 | 0.133 | 0.897 |
TC vs. CC | 1.880 (1.162–3.044) | 0.010 | 0.000 | 79.3 | 0.133 | 0.427 | |||
TT + TC vs. CC | 2.042 (1.240–3.361) | 0.005 | 0.000 | 83.7 | 0.133 | 0.529 | |||
TT vs. CC + TC | 1.310 (1.114–1.542) | 0.001 | 0.208 | 30.3 | 0.260 | 0.918 | |||
T vs. C | 1.503 (1.126–2.006) | 0.006 | 0.000 | 81.8 | 0.230 | 0.580 | |||
Asian | 2 | TT vs. CC | 1.242 (0.983–1.569) | 0.070 | 0.108 | 61.2 | 1.000 | – | |
TC vs. CC | 1.074 (0.939–1.227) | 0.298 | 0.163 | 48.5 | 1.000 | – | |||
TT + TC vs. CC | 1.077 (0.976–1.190) | 0.140 | 0.102 | 62.6 | 1.000 | – | |||
TT vs. CC + TC | 1.222 (0.942–1.585) | 0.131 | 0.234 | 29.4 | 1.000 | – | |||
T vs. C | 1.375 (0.823–2.297) | 0.223 | 0.041 | 76.1 | 1.000 | – | |||
Caucasian (Iran) | 2 | T vs. C | 1.007 (0.891–1.139) | 0.907 | 0.584 | 0.0 | 1.000 | – | |
Egyptian | 3 | TT vs. CC | 3.060 (1.529–6.122) | 0.002 | 0.046 | 67.5 | 0.296 | 0.895 | |
TC vs. CC | 3.123 (1.339–7.284) | 0.008 | 0.002 | 84.2 | 0.296 | 0.080 | |||
TT + TC vs. CC | 3.363 (1.477–7.655) | 0.004 | 0.001 | 86.1 | 0.296 | 0.168 | |||
TT vs. CC + TC | 1.462 (1.169–1.829) | 0.001 | 0.260 | 25.8 | 0.296 | 0.981 | |||
T vs. C | 2.276 (1.295–4.001) | 0.004 | 0.000 | 87.0 | 0.296 | 0.247 | |||
codon 10 | Total | 9 | CC vs. TT | 0.961 (0.802–1.151) | 0.664 | 0.473 | 0.0 | 1.000 | 0.880 |
codon 25 | CT vs. TT | 0.961 (0.884–1.045) | 0.350 | 0.975 | 0.0 | 0.917 | 0.301 | ||
CC + CT vs. TT | 0.972 (0.911–1.037) | 0.390 | 0.987 | 0.0 | 0.917 | 0.726 | |||
CC vs. TT + CT | 1.011 (0.823–1.241) | 0.917 | 0.179 | 30.0 | 0.917 | 0.676 | |||
C vs. T | 0.980 (0.907–1.060) | 0.613 | 0.648 | 0.0 | 1.000 | 0.671 | |||
Asian | 2 | CC vs. TT | 1.074 (0.801–1.441) | 0.632 | 0.170 | 46.8 | 1.000 | – | |
CT vs. TT | 1.929 (0.804–1.073) | 0.318 | 0.935 | 0.0 | 1.000 | – | |||
CC + CT vs. TT | 0.973 (0.873–1.085) | 0.624 | 0.514 | 0.0 | 1.000 | – | |||
CC vs. TT + CT | 1.245 (0.886–1.748) | 0.206 | 0.107 | 61.5 | 1.000 | – | |||
C vs. T | 1.029 (0.903–1.174) | 0.666 | 0.138 | 54.5 | 1.000 | – | |||
Caucasian | 4 | CC vs. TT | 0.950 (0.703–1.284) | 0.737 | 0.350 | 8.6 | 1.000 | 0.976 | |
CT vs. TT | 1.000 (0.876–1.142) | 1.000 | 0.891 | 0.0 | 0.734 | 0.818 | |||
CC + CT vs. TT | 0.991 (0.891–1.101) | 0.859 | 0.930 | 0.0 | 1.000 | 0.448 | |||
CC vs. TT + CT | 0.934 (0.668–1.305) | 0.689 | 0.220 | 32.1 | 1.000 | 0.861 | |||
C vs. T | 0.979 (0.865–1.109) | 0.740 | 0.605 | 0.0 | 1.000 | 0.844 | |||
Mix (Brazilian) | 2 | CC vs. TT | 0.853 (0.587–1.241) | 0.406 | 0.370 | 0.0 | 1.000 | – | |
CT vs. TT | 0.904 (0.756–1.082) | 0.270 | 0.916 | 0.0 | 1.000 | – | |||
CC + CT vs. TT | 0.924 (0.806–1.058) | 0.253 | 0.851 | 0.0 | 1.000 | – | |||
CC vs. TT + CT | 0.912 (0.588–1.417) | 0.683 | 0.279 | 14.6 | 1.000 | – | |||
C vs. T | 0.921 (0.779–1.090) | 0.338 | 0.477 | 0.0 | 1.000 | – | |||
Total | 11 | CC vs. GG | 0.744 (0.455–1.218) | 0.240 | 0.811 | 0.0 | 0.764 | 0.984 | |
CG vs. GG | 0.940 (0.567–1.559) | 0.811 | 0.003 | 63.7 | 0.592 | 0.748 | |||
CC + CG vs. GG | 0.935 (0.570–1.534) | 0.790 | 0.003 | 64.6 | 0.592 | 0.740 | |||
CC vs. GG + CG | 0.809 (0.483–1.356) | 0.421 | 0.931 | 0.0 | 0.548 | 0.879 | |||
C vs. G | 1.000 (0.670–1.494) | 1.000 | 0.006 | 59.6 | 0.436 | 0.662 | |||
Asian | 2 | CC vs. GG | 0.917 (0.530–1.588) | 0.758 | 0.714 | 0.0 | 1.000 | – | |
CG vs. GG | 0.896 (0.680–1.181) | 0.435 | 0.607 | 0.0 | 1.000 | – | |||
CC + CG vs. GG | 0.917 (0.732–1.148) | 0.449 | 0.737 | 0.0 | 1.000 | – | |||
CC vs. GG + CG | 0.951 (0.536–1.687) | 0.863 | 0.712 | 0.0 | 1.000 | – | |||
C vs. G | 0.923 (0.733–1.163) | 0.498 | 0.899 | 0.0 | 1.000 | – | |||
Caucasian | 5 | CC vs. GG | 0.274 (0.063–1.190) | 0.084 | 0.513 | 0.0 | 1.000 | 0.880 | |
CG vs. GG | 1.215 (0.563–2.623) | 0.620 | 0.042 | 59.7 | 0.806 | 0.333 | |||
CC + CG vs. GG | 1.130 (0.500–2.553) | 0.769 | 0.023 | 64.8 | 0.806 | 0.349 | |||
CC vs. GG + CG | 0.339 (0.072–1.600) | 0.172 | 0.767 | 0.0 | 1.000 | 0.882 | |||
C vs. G | 1.079 (0.518–2.247) | 0.839 | 0.031 | 62.4 | 0.462 | 0.339 | |||
Mix (Brazilian) | 2 | CC vs. GG | 0.890 (0.117–6.743) | 0.910 | 0.651 | 0.0 | 1.000 | – | |
CG vs. GG | 0.648 (0.101–4.170) | 0.648 | 0.014 | 83.6 | 1.000 | – | |||
CC + CG vs. GG | 0.691 (0.102–4.690) | 0.705 | 0.010 | 84.8 | 1.000 | – | |||
CC vs. GG + CG | 0.984 (0.126–7.706) | 0.988 | 0.762 | 0.0 | 1.000 | – | |||
C vs. G | 0.769 (0.129–4.591) | 0.774 | 0.012 | 84.0 | 1.000 | – | |||
Mix | 3 | C vs. G | 1.038 (0.272–3.965) | 0.956 | 0.003 | 83.3 | 1.000 | 0.205 | |