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Table 5 Clinical and laboratory features in the observational cohort for the MgSO4 exposed and control groupsa

From: Assessing the efficacy and safety of magnesium sulfate for management of autonomic nervous system dysregulation in Vietnamese children with severe hand foot and mouth disease

  MgSO4 (N = 33) Control (N = 12)
Demographic and clinical featuresb
 Age (months) 36 (12, 153) 15 (6, 45)
 Sex (female) 7 (21) 6 (50)
 Weight (kg) 18 (9, 55) 10 (7, 20)
 Illness day at T = 0 4 (2, 8) 4 (1, 7)
 Fever (>  37.50 C) 26 (79) 11 (92)
 Skin ANS featuresc 1 (3) 0 (0)
 Tachycardiad 7 (21) 2 (17)
 Systolic BP at T = 0 140 (122, 200) 134 (119, 168)
 Diastolic BP at T = 0 70 (55, 110) 64 (54, 88)
 Tachypnea for age 16 (55) 9 (75)
 Irregular breathing 3 (12) 2 (18)
 Neurological abnormalitiese 1 (3) 0 (0)
Laboratory investigationsb
 Hb (g/dl) 11.9 (9.1, 14.9) 13.1 (9.0, 15.0)
 WBC (×109/l) 12.0 (5.7, 17.7) 12.6 (9.9, 26.7)
 CK-MB (IU/l) 23.9 (11.7, 71.7) 36.8 (17.5, 159.2)
 Troponin I (pg/ml) 11 (00, 48) 13 (0, 772)
 Blood sugar (mmol/l) 5.9 (4.2, 9.1) 5.7 (4.2, 10.9)
 Lab-confirmed EV infection 25 (76) 12 (100)
  EV-A71 positive 23 (70) 12 (100)
  Other EV positivef 2 (6) 0
  1. Summary statistic is absolute count (%) for categorical variables and median (range) for continuous data
  2. aFeatures assessed within the 24 h before the actual/potential time to start MgSO4 (T = 0)
  3. bMissing data for tachypnea in 4 cases in the MgSO4 group. For the lab investigations data were missing in less than 5% of cases for most variables, except that CK-MB and Troponin were only measured in patients with tachycardia sustained > 170 bpm (MgSO4 Group – 18 cases, Control group – 6 cases)
  4. cSkin manifestations of autonomic nervous system (ANS) dysregulation
  5. dTachycardia: Heart rate sustained > 150 beats/min, adjusted down by 10 for each 1oC of fever above 37.0 °C
  6. eMyoclonic jerks were not observed during the 24 h before T = 0 in any patient, while limb tremor/ataxia was present in 1 case in the MgSO4 exposed group
  7. fIncluding 1 case with Coxsackievirus (CV) A 16, 1 case with an undefined enterovirus, all other cases PCR negative