Table 6 The 7 selected SNPs association with sepsis (n = 305, adjusted by sex and age)
SNP | Model | Genotype | Normal controls | Sepsis patients | OR (95% CI) | P value | AIC | BIC |
|---|---|---|---|---|---|---|---|---|
rs2269715 | Codominant | C/C | 59 (39.6%) | 58 (37.18%) | 1 | 0.888 | − 445.35 | − 429.95 |
C/G | 70 (46.98%) | 79 (50.64%) | 1.08 (0.57, 2.04) | Â | Â | Â | ||
G/G | 19 (12.75%) | 8 (5.13%) | 1.16 (0.62, 2.17) | Â | Â | Â | ||
Dominant | C/C | 59 (39.6%) | 58 (37.18%) | 1 | 0.91 | −445.40 | − 430.00 | |
C/G-G/G | 89 (60.4%) | 87 (55.77%) | 0.97 (0.61, 1.56) | Â | Â | Â | ||
Recessive | C/C-C/G | 129 (87.25%) | 137 (87.82%) | 1 | 0.69 | −445.42 | −430.02 | |
G/G | 19 (12.75%) | 8 (5.13%) | 1.12 (0.63, 1.99) | Â | Â | Â | ||
Overdominant | C/C-G/G | 78 (52.35%) | 66 (42.31%) | 1 | 0.79 | −445.50 | −430.10 | |
C/G | 70 (46.98%) | 79 (50.64%) | 0.94 (0.59, 1.49) | Â | Â | Â | ||
rs2721068 | Codominant | T/T | 7 (4.7%) | 19 (12.18%) | 1 | 0.028 | −451.43 | − 436.03 |
T/C | 58 (38.93%) | 66 (42.31%) | 3.67 (1.38, 9.77) | Â | Â | Â | ||
C/C | 84 (56.38%) | 71 (45.51%) | 1.33 (0.78, 2.18) | Â | Â | Â | ||
Dominant | T/T | 7 (4.7%) | 19 (12.18%) | 1 | 0.016 | −451.24 | −435.84 | |
T/C-C/C | 142 (95.3%) | 137 (87.82%) | 3.24 (1.25, 8.44) | Â | Â | Â | ||
Recessive | T/T-T/C | 65 (43.62%) | 85 (54.49%) | 1 | 0.059 | − 448.12 | −432.72 | |
C/C | 84 (56.38%) | 71 (45.51%) | 1.57 (0.98, 2.50) | Â | Â | Â | ||
Overdominant | T/T-C/C | 92 (61.07%) | 90 (57.69%) | 1 | 0.719 | − 444.45 | −429.05 | |
T/C | 58 (38.93%) | 66 (42.31%) | 0.92 (0.58, 1.45) | Â | Â | Â | ||
rs17446614 | Codominant | A/A | 2 (1.34%) | 3 (1.92%) | 1 | 0.061 | − 452.91 | − 437.51 |
A/G | 35 (23.49%) | 20 (12.82%) | 0.41 (0.04, 4.58) | Â | Â | Â | ||
G/G | 110 (73.83%) | 133 (85.25%) | 0.48 (0.25, 0.90) | Â | Â | Â | ||
Dominant | A/A | 2 (1.34%) | 3 (1.92%) | 1 | 0.545 | −446.91 | − 431.51 | |
A/G-G/G | 145 (97.32%) | 153 (98.08%) | 0.47 (0.04, 5.33) | Â | Â | Â | ||
Recessive | A/A-A/G | 37 (24.84%) | 23 (14.75%) | 1 | 0.018 | −453.18 | −437.78 | |
G/G | 110 (73.83%) | 133 (85.25%) | 0.47 (0.026, 0.88) | Â | Â | Â | ||
Overdominant | A/A-G/G | 112 (75.17%) | 136 (87.18%) | 1 | 0.028 | −452.61 | −437.21 | |
A/G | 35 (23.49%) | 20 (12.82%) | 1.86 (1.07, 3.23) | Â | Â | Â |