Table 1 Publications included in meta-analysis
No. | Author | HIV infe. | Vaccine | Outcome | Age group | Schedule | Study design | Sample size | Risk of bias |
|---|---|---|---|---|---|---|---|---|---|
1 | Klugman et al. [20] | HI, HUI | PCV9 | First episode of IPD: All serotype, vaccine and non-vaccine serotypes; during 2.3 years of follow up | Less than 5 years | 3 doses at 6, 10, 14 WK; no booster dose | Randomized trial | 39,836 | Low |
2 | Madhi et al. [26] | HI, HUI | PCV9 | First episode of IPD: All, vaccine and non-vaccine serotypes; during 6.16 years of follow up | Less than 7 years | 3 doses at 6, 10, 14 WK; no booster dose | Randomized trial | 39,836 | Low |
3 | Madhi et al. [27] | HI, HUI | PCV9 | Bacteremic pneumococcal pneumoniaa: all and vaccine serotypes; during 2.3 years of follow up | Less than 5 years | 3 doses at 6, 10, 14 WK; no booster dose | Randomized trial | 39,836 | Low |
4 | Cohen et al. [19] | HI, HUI | PCV7 | IPD: All and PCV7 serotypes | Less than 1 year | 2 + 1 at 6 and 14 WK, and 1 at 9 month (two or more) | Matched case control | 1395 | Low |
5 | Cohen et al. [18] | HI, HUI | PCV13 | IPD: All, PCV7 and PCV13 serotypes | Less than 5 years | 2 + 1 at 6 and 14 WK, and 1 at 9 months (two or more) | Matched case control | 1716 | Low |
6 | Mollendorf et al. [28] | HUIa | PCV7 | IPD: vaccine serotypesa | Less than 5 years | 2 + 1 at 6 and 14 WK, and 1 at 9 months (two or more) | Matched case control |  | low |
7 | Steenhoff et al. [29] | HI | PCV7 | IPD: vaccine and non-vaccine serotypes | Less than 5 yearsa | 3 + 1 at 2, 4, 6 and 12–15 months | Retrospective Pre-post | 256 | unclear |
8 | Nzenze et al. [30] | HI, HUI | PCV7, PCV13 | IPD: All, PCV7, PCV13 and non-vaccine serotypes | Less than 2 and 2–5 years | 2 + 1 at 6 and 14 WK, and 1 at 9 months | Pre-post | 160,000 | unclear |
9 | Gottberg et al. [5] | HI, HUI | PCV7, PCV13 | IPD: All, PCV7, PCV13 and non-vaccine serotypes | Less than 2 years | 2 + 1 at 6 and 14 WK, and 1 at 9 months | National Pre-post | ≈2,000,000 | Unclear |
10 | Mollendorf et al. [4] | HI, HUI | PCV13 | IPD: All serotypes | Less than 1 year | 2 + 1 at 6 and 14 WK, and 1 at 9 months | Pre-post | 937a | Unclear |