Skip to main content

Table 1 Publications included in meta-analysis

From: Effectiveness of pneumococcal conjugate vaccination against invasive pneumococcal disease among children with and those without HIV infection: a systematic review and meta-analysis

No. Author HIV infe. Vaccine Outcome Age group Schedule Study design Sample size Risk of bias
1 Klugman et al. [20] HI, HUI PCV9 First episode of IPD: All serotype, vaccine and non-vaccine serotypes; during 2.3 years of follow up Less than 5 years 3 doses at 6, 10, 14 WK; no booster dose Randomized trial 39,836 Low
2 Madhi et al. [26] HI, HUI PCV9 First episode of IPD: All, vaccine and non-vaccine serotypes; during 6.16 years of follow up Less than 7 years 3 doses at 6, 10, 14 WK; no booster dose Randomized trial 39,836 Low
3 Madhi et al. [27] HI, HUI PCV9 Bacteremic pneumococcal pneumoniaa: all and vaccine serotypes; during 2.3 years of follow up Less than 5 years 3 doses at 6, 10, 14 WK; no booster dose Randomized trial 39,836 Low
4 Cohen et al. [19] HI, HUI PCV7 IPD: All and PCV7 serotypes Less than 1 year 2 + 1 at 6 and 14 WK, and 1 at 9 month (two or more) Matched case control 1395 Low
5 Cohen et al. [18] HI, HUI PCV13 IPD: All, PCV7 and PCV13 serotypes Less than 5 years 2 + 1 at 6 and 14 WK, and 1 at 9 months (two or more) Matched case control 1716 Low
6 Mollendorf et al. [28] HUIa PCV7 IPD: vaccine serotypesa Less than 5 years 2 + 1 at 6 and 14 WK, and 1 at 9 months (two or more) Matched case control   low
7 Steenhoff et al. [29] HI PCV7 IPD: vaccine and non-vaccine serotypes Less than 5 yearsa 3 + 1 at 2, 4, 6 and 12–15 months Retrospective Pre-post 256 unclear
8 Nzenze et al. [30] HI, HUI PCV7, PCV13 IPD: All, PCV7, PCV13 and non-vaccine serotypes Less than 2 and 2–5 years 2 + 1 at 6 and 14 WK, and 1 at 9 months Pre-post 160,000 unclear
9 Gottberg et al. [5] HI, HUI PCV7, PCV13 IPD: All, PCV7, PCV13 and non-vaccine serotypes Less than 2 years 2 + 1 at 6 and 14 WK, and 1 at 9 months National Pre-post ≈2,000,000 Unclear
10 Mollendorf et al. [4] HI, HUI PCV13 IPD: All serotypes Less than 1 year 2 + 1 at 6 and 14 WK, and 1 at 9 months Pre-post 937a Unclear
  1. Abbreviations: WK Weeks, HI HIV-infected, HUI HIV-uninfected, IPD invasive pneumococcal disease, PCV pneumococcal conjugate vaccine
  2. aDue to methodological considerations or unavailability of primary information only this part of results was included in the meta-analysis