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Table 4 Prevalence, sensitivities and specificities, PPV and NPV in confirmation of dengue infection

From: Risk prediction for severe disease and better diagnostic accuracy in early dengue infection; the Colombo dengue study

Parameters

RT-PCRa test was assumed as a perfect gold standard (%)

Bayesian latest class model (%)

Prevalence

65.6 (56.4–73.8)

53.0 (43.0–62.9)

RT PCRa

 Sensitivity

96.6 (90.1–99.7)

 Specificity

69.8 (55.2–82.5)

 PPV

78.4 (66.3–88.5)

 NPV

94.8 (84.7–99.5)

RT-LAMPa

 Sensitivity

73.8 (62.5–82.7)

93.4 (80.9–99.9)

 Specificity

95.2 (82.6–99.2)

99.2 (91.7–100)

 PPV

96.7 (87.6–99.4)

99.3 (92.3–100)

 NPV

65.6 (52.2–77.0)

93.1 (78.2–99.9)

NS 1 test

 Sensitivity

61.3 (49.7–71.7)

75.1 (63.2–84.9)

 Specificity

85.7 (70.8–94.1)

89.0 (77.3–96.9)

 PPV

89.1 (77.1–95.5)

88.5 (75.3–97.0)

 NPV

53.7 (41.2–65.8)

76.0 (63.5–85.8)

  1. aRT-PCR Reverse transcription and polymerase chain reaction, NS1 NS1 antigen test, RT-LAMP Reverse transcription loop-mediated isothermal amplification, PPV Positive predictive value, NPV Negative predictive value