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Table 3 Kaplan–Meier analysis of prognostic factors of 90-day survival in 61 patients with chronic disseminated candidiasis

From: Chronic disseminated candidiasis manifesting as hepatosplenic abscesses among patients with hematological malignancies

  Total
(n = 61)
Alive
(n = 49)
Death
(n = 12)
Univariate
p
Multivariate
p
Age     0.539  
 Age > =65 years 9 8 1   
 Age < 65 years 52 41 11   
Gender     0.427  
 Men 32 27 5   
 Women 29 22 7   
Hematological subtype     < 0.001 0.225
 AML 38 34 4   
 ALL 13 8 5   
 Lymphoma 7 5 2   
 CML/MPN 1 1 0   
 CLL 0 0 0   
 Myeloma 1 1 0   
 MDS/SAA 1 0 1   
Preceding allogeneic transplantation     < 0.001 0.128
 Yes 5 1 4   
 No 56 48 8   
Neutropenia<=500 / mm3     0.650  
 Yes 19 16 3   
 No 42 33 9   
Thrombocytopenia     0.905  
 Platelet > = 20000 / mm3 52 42 10   
 Platelet < 20000 / mm3 9 7 2   
Proven or Probable CDC     0.492  
 Yes 16 12 4   
 No 45 37 8   
Initial anti-fungal agent     < 0.001 0.624
 Amphotericin B 9 7 2   
 Fluconazole 35 29 6   
 Itraconazole 1 0 1   
 Voriconazole 6 6 0   
 Posaconazole 2 1 1   
 Caspofungin 1 0 1   
 Micafungin 3 3 0   
 Anidulafungin 2 1 1   
 none 2 2 0   
Hepatitis B carrier     0.186  
 Yes 7 7 0   
 No 54 42 12   
Diabetes mellitus     0.854  
 Yes 9 7 2   
 No 52 42 10   
Shock     < 0.001 0.016
 Yes 8 0 8   
 No 53 49 4   
  1. Abbreviations: AML acute myeloid leukemia, ALL acute lymphoblastic leukemia, CML chronic myeloid leukemia, MPN myeloid proliferative neoplasm, CLL chronic lymphoid leukemia, MDS myelodysplastic syndrome, SAA severe aplastic anemia, CDC chronic disseminated candidiasis