Incidence and predictors of second-line antiretroviral treatment failure among adults living with HIV in Amhara region: a multi-centered retrospective follow-up study

Table 1 Test of proportional hazard (PH) assumption using Schoenfeld residuals from second-line ART among adults in Amhara Region (February 2008–April 2016)

Variables	Correlation	Chi-square	P-value
Age
15–24	Reference
25–34	−0.016	0.069	0.791
35–44	−0.004	0.004	0.947
≥ 45	− 0.055	0.805	0.369
Gender
Female	Reference
male	0.011	0.032	0.857
BMI(kg/m²)
< 18.5	−0.106	2.900	0.089
18.5–24.99	Reference
> 25	0.037	0.327	0.567
CD4 count at switch
≥ 100 cells/mm³	Reference
< 100 cells/mm³	−0.089	2.098	0.147
Regimen modification
Yes	Reference
No	0.002	0.001	0.973
ART adherence
Good	Reference
Fair	0.066	1.132	0.287
Poor	0.079	1.612	0.204
WHO clinical stage
I	Reference
II	0.045	0.519	0.471
III	0.052	0.728	0.393
IV	0.079	1.679	0.195
Isoniazid Preventive Therapy (INH) given
Yes	Reference
No	0.013	0.044	0.833
Functional status at switch
Working	Reference
Ambulatory	−0.056	0.867	0.352
bedridden	−0.023	0.128	0.719
Opportunistic Infections (OI)
Yes	Reference
No	0.093	2.290	0.130
Second-line regimen
ABC-ddI-LPV/r	Reference
TDF-3TC-LPV/r	−0.058	0.906	0.341
AZT-3TC-LPV/r	0.017	0.072	0.788
Others^a	−0.077	1.512	0.219

^a = (ABC-ddI-NFV, AZT-3TC-ATV/r, TDF-3TC-ATV/r, ABC-3TC-LPV/r, and ABC-3TC-ATV/r)

ISSN: 1471-2334