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Table 7 Genotypic and phenotypic drug susceptibility testing pattern of SNPT isolates, August 01, 2017- January 05, 2018

From: Prevalence of tuberculosis, multidrug resistant tuberculosis and associated risk factors among smear negative presumptive pulmonary tuberculosis patients in Addis Ababa, Ethiopia

Drug susceptibility testing Drugs Status (Resistant/Sensitive)
Resistant No. (%) Sensitive No. (%)
Genotype MTBDRplus Ver. 2 Rif 03 (11.54) 23 (88.46)
INH 07 (26.9) 19 (73.1)
MDR TB 03 (11.54) 23 (88.46)
  Drugs Final drug concentration tested Drug status (Sensitive/ Resistant)
Resistant No. (%) Sensitive No. (%)
First line MGIT DST STR 1.0 μg/ml 03 (15%) 17 (85%)
INH 0.1 μg/ml 03 (15%) 17 (85)
RIF 1.0 μg/ml 02 (10%) 18 (90%)
ETM 5.0 μg/ml 01 (5%) 19 (95%)
MDR TB   02 (10%) 18 (90)
  1. First Line MGIT DST; the reason for variation with LPA is that 06 isolates from which 1 MDR Isolate, 03 were INH resistant by LPA was not finalized
  2. Operationalized definitions
  3. 1. Smear Negative Pulmonary Tuberculosis (SNPT):- Is PTB that was initially negative for two (spot-spot) consecutive sputum smear examinations and later diagnosed positive by other advanced TB diagnostic tools [11]
  4. 2. Smear Negative Presumptive Pulmonary Tuberculosis (SNPPT) patients: - Are patients who have signs and symptoms and are presumptive to be diagnosed with pulmonary tuberculosis but two of their consecutive sputum samples are microscopically negative [37]
  5. 3. Alcohol consumption: is when a person takes alcohol every day and who was taking alcohol previously, but he/ she stopped drinking now
  6. 4. Smokers: are persons who smokes cigarettes every day and who was smoking previously, but he/ she stopped now
  7. 5. Contact with TB patient: according to WHO, these are people who have close contact with infectious TB and have high risk for infection with TB