Skip to main content

Table 4 Predictors of in-hospital all-cause mortality among adult patients with community-acquired sepsis by survival group

From: Clinical and microbiological characteristics and outcomes of community-acquired sepsis among adults: a single center, 1-year retrospective observational cohort study from Hungary

ParametersaSurvival (n = 184)Exitus (n = 30)UnivariateMultivariate
OR (95% CI)p valueOR (95% CI)p value
Age (years, median ± IQR, min–max)58.4 ± 34.0 (18–93)66.7 ± 21.0 (26–90)0.98 (0.96–1.01)0.06
Male gender76 (41.3)16 (53.3)1.62 (0.75–3.52)0.226.35 (1.24–32.51)0.03
Arterial hypertension109 (59.2)23 (76.7)2.22 (0.9–5.26)0.09
Chronic heart disease78 (42.4)16 (53.3)1.56 (0.72–3.45)0.27  
Chronic lung disease25 (13.6)9 (30.0)2.7 (1.11–6.66)0.03
Chronic kidney disease43 (23.4)7 (23.3)1.0 (0.4–2.49)0.99  
Chronic liver disease44 (23.9)11 (36.7)1.85 (0.81–4.17)0.14  
Diabetes mellitus52 (28.3)9 (30.0)1.09 (0.13–2.56)0.85  
Malignancy20 (10.9)2 (6.7)0.59 (0.13–2.63)0.49  
Corticosteroid use14 (7.6)3 (10.0)1.35 (0.36–5.0)0.65  
Immunosuppression46 (25.0)11 (36.7)1.72 (0.76–3.85)0.19  
Cerebrovascular disease44 (23.9)14 (46.7)2.78 (1.27–6.25)0.01
Intravenous drug use7 (3.8)0n.a.n.a.  
Excess alcohol use33 (17.9)12 (40.0)3.0 (1.33–7.14)0.01
No. of comorbidities (per patient, median ± IQR, min–max)3.0 ± 3.0 (0–8)4.0 ± 2.0 (0–7)1.32 (1.06–1.61)0.08
Charlson score (median ± IQR, min–max)4.0 ± 5.3 (0–12)6.0 ± 4.8 (0–9)1.11 (0.98–1.28)0.09
Absence of fever at diagnosis14 (7.6)8 (26.7)4.42 (1.67–11.71)0.017.35 (1.1–51.8)0.04
Presence of shock at diagnosis35 (19.0)26 (86.7)27.78 (9.09–83.3)< 0.0133.93 (6.72–141.47)< 0.01
Identifiable source of sepsis163 (88.6)27 (90.0)1.16 (0.32–4.17)0.82
Source control36 (19.6)3 (10.0)0.46 (0.13–1.59)0.220.09 (0.01–0.63)0.02
Rate of bacteraemia92 (50.0)17 (56.7)1.29 (0.59–2.86)0.49
Need for ICU admittance36 (19.6)22 (73.3)11.11 (4.55–25.0)< 0.018.39 (1.67–42.05)0.01
Need for supportive therapy63 (34.2)24 (80.0)7.69 (2.94–20.0)< 0.01
Duration of antibiotic therapy (days, median ± IQR, min–max)11.0 ± 4.0 (1–50)6.5 ± 12.8 (1–30)1.09 (1.02–1.19)0.01*n.a. 
Adequate empirical antimicrobial therapy164 (89.1)26 (86.7)0.71 (0.22–2.27)0.56
Escalation of antimicrobial therapy28 (15.2)8 (26.7)2.0 (0.81–5.0)0.13
De-escalation of antimicrobial therapy27 (14.7)3 (10.0)0.64 (0.18–2.27)0.480.14 (0.02–1.06)0.04
Empirical antimicrobial combinations37 (20.1)8 (26.7)1.42 (0.59–3.45)0.43  
Penicillins as empirical choice22 (12.0)4 (13.3)1.13 (0.36–3.57)0.83  
Cephalosporins as empirical choice129 (70.1)24 (80.0)1.69 (0.74–4.35)0.38  
Carbapenems as empirical choice13 (7.1)3 (10.0)1.47 (0.39–5.56)0.57  
  1. a All parameters are reported in absolute numbers and relative percentages (n, %), unless otherwise specified
  2. * The parameter was not included in the final model as co-linearity was not proven by the Box-Tidwell test (p < 0.05)
  3. n.a. Not applicable.