Table 1 Demographics of cryptococcal meningitis research participants
Demographics | Overall | Phlebitis During Induction | No Phlebitis During Induction | P-value | |||
|---|---|---|---|---|---|---|---|
N | Median [IQR] or N (%) | N | Median [IQR] or N (%) | N | Median [IQR] or N (%) | ||
Age, years | 696 | 35 [30, 41] | 125 | 35 [30, 40] | 571 | 35 [30, 41] | 0.53 |
Women | 696 | 275 (39.5%) | 125 | 47 (38%) | 571 | 228 (40%) | 0.63 |
Weight, kg | 573 | 52 [48, 60] | 97 | 53 [49, 60] | 476 | 52 [48, 60] | 0.82 |
Receiving HIV therapy | 695 | 367 (53%) | 125 | 59 (47%) | 570 | 308 (54%) | 0.17 |
Glasgow Coma Score < 15 | 695 | 295 (42%) | 125 | 47 (38%) | 570 | 248 (44%) | 0.23 |
Duration of HIV, months | 656 | 4.3 [0.3, 38.1] | 116 | 4.1 [0.3, 50.8] | 540 | 4.3 [0.3, 37.2] | 0.79 |
CD4 T cell count, cells/μL | 661 | 16 [6, 49] | 122 | 15 [6, 50] | 539 | 17 [6, 49] | 0.63 |
Initial Meningitis episode | 696 | 607 (87%) | 125 | 118 (94%) | 571 | 489 (86%) | < 0.01 |
Second Meningitis episode | 696 | 89 (13%) | 125 | 7 (5.6%) | 571 | 82 (14%) | |
CSF Culture, log10 CFU/mL | 692 | 4.6 [2.8, 5.4] | 124 | 4.5 [3.1, 5.3] | 568 | 4.6 [2.8, 5.4] | 0.89 |
Sterile cryptococcal culture | 692 | 74 (11%) | 124 | 5 (4.0%) | 568 | 69 (12%) | < 0.01 |
CSF opening pressure, cm H2O | 607 | 27 [18, 40] | 105 | 27 [19, 38] | 502 | 27 [18, 41] | 0.63 |
Opening pressure > 25 cm H2O | 607 | 336 (55%) | 105 | 55 (52%) | 502 | 281 (56.%) | 0.50 |
CSF white cells/μL | 671 | < 5 [< 5, 45] | 121 | < 5 [< 5, 45] | 550 | < 5 [< 5, 45] | 0.12 |
CSF white cells > 5 cells/μL | 671 | 243 (36%) | 121 | 36 (30%) | 550 | 207 (38%) | 0.10 |
CSF protein, mg/dL | 594 | 49 [23, 100] | 118 | 42 [25, 100] | 476 | 50 [22, 100] | 0.83 |