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Table 1 Summary of studies included in the analysis

From: Diversity of infectious aetiologies of acute undifferentiated febrile illnesses in south and Southeast Asia: a systematic review

First author, year and reference

Country

Design study

Study duration

In patients/ outpatients

Number of patients

Age range

Adult/Children only

Sex

Duration of fever (mean duration)

Abhilash et al., 2016 [20]

India

Prospective observational study

12 months

OPD + ED

1258

> 15 years

Adults + children

M = 680

F = 568

3–14 days

Ahmad et al., 2016 [44]

India

Retrospective observational study

12 months

IP

298

> 2 years

Adults + children

Not specified

AUFI

Andrews et al., 2014 [45]

India

Retrospective and Patient admitted prospective study

2 months

IP

369

> 13 years

Adults

F = 118

M = 251

AUFI

Arora et al., 2014 [46]

India

Retrospective study

24 months

IP + OPD

38,635

All ages groups

Adult + Children

Not specified

AUF

Capeding et al., 2013 [11]

Indonesia, Malaysia, Philippines, Thailand and Vietnam

Active fever surveillance, cohort study

9.8 months

Community based

289

2–14 years

Children

Not specified

< 14 days

Chheng et al., 2013 [42]

Cambodia

Prospective study

12 months

IP

1225

< 16 years

Children

M = 668

F = 557

< 28 days

Chikkaveerariah et al., 2016 [47]

India

Prospective observational study

24 months

IP

150

> 14 years

Adults

F = 69

M = 81

AUFI

Chrispal et al., 2010 [1]

India

Prospective observational study

12 months

IP

398

> 16 years

Mean 39.5

Adults

M = 239

F = 159

5–21 days

Das et al., 2015 [48]

India

Cross-sectional study

6 months

IP

205

All ages

Adults + Children

F = 89

M = 116

Acute febrile illness

Ellis et al., 2006 [49]

Thailand

Prospective study

33 months

IP + OPD

613

20–87 years

Adults

M = 325

F = 288

Fever over previous 48 h and fever longer than 48 h cause of fever not yet known

Gopalakrishnan et al., 2013 [21]

India

Prospective observational

18 months

IP

403

> 16 years

Adults

M = 264

F = 139

5–14 days

Joshi et al., 2008 [22]

India

Retrospective review of electronic discharge summaries

6 months

IP

1197

> 12 years

Adults

M = 640

F = 557

< 14 days

Kammili et al., 2013 [23]

India

Prospective descriptive hospital based study

2 months

IP

100

All ages

Both children and adults

Not specified

> 24 h

Kashinkunti et al., 2013 [37]

India

Prospective observational

Not specified

IP

100

> 16 years

Adults

M = 58

F = 42

< 15 days

Kasper et al., 2012 [24]

Cambodia

Fever surveillance study

Not specified

OPD

9997

> 2 years

Mean 19.6

Median 16.9

Adults and children

M = 5398

F = 4599

< 10 days

Kumar et al., 2008 [39]

India

Prospective study

12 months

OPD

298

6 months −12 years

Children

M = 117

F = 181

< 15 days

Laoprasopwattana et al., 2012 [25]

Thailand

Prospective cohort study

4 months

IP + OPD

50

1 month −15 years

Children

Not specified

< 7 days

Leelarasamee et at., 2004 [2]

Thailand

Prospective epidemiological study

36 months

OPD

1137

> 2 years

Adults + Children

Not specified

< 1 day

Mayxay et al., 2013 [26]

Laos

Prospective study

30 months

IP + OPD

1938

5–49

median 19

Adults/children

M = 1124

F = 814

< 8 days

McGready et al., 2010 [50]

Thailand

Prospective cohort study

28 months

IP

409

> 15 years

Pregnant females only

M = 467

F = 409

Any fever

Mittal et al., 2015 [51]

India

Retrospective observational study

12 months

IP + OPD

2547

> 18 years

Adults

F = 884

M = 1663

AUFI

Murdoch et al., 2004 [36]

Nepal

Prospective study

3 months

IP + OPD

876

> 14 years

Median 27

Adults

F = 409

24 h

Oishr et al., 2006 [27]

Philippines

Prospective study

24 months

IP

503

2–17 years

Children

M = 298

F = 205

< 5 days

Phuong et al., 2006 [28]

Vietnam

Prospective study

12 months

OPD

2096

All ages

Both children and adults

M = 1229

F = 865

< 14 days

Pradutkanchana et al., 2003 [7]

Thailand

Prospective study

1 month

IP

180

Less than 15 years

Children

Not specified

< 21 days

Punjabi et al., 2012 [43]

Indonesia

Prospective study

27 months

IP

226

1–80 years

Adults and children

M = 127

F = 99

1–30 days

Rafizah et al., 2012 [52]

Malaysia

Hospital-based cross sectional study

6 months

IP

999

> 18 years

Adults

F = 543

M = 456

Acute fever

Rani et al., 2016 [53]

India

Retrospective study

6 Months

IP + OPD

200

All ages

Adults + children

F = 82

M = 118

Acute febrile illness

Ray et al., 2012 [29]

India

Prospective descriptive study

12 months

IP + OPD

540

All age groups

Both children and adults

M = 329

F = 211

< 7 days

Reller et al., 2011 [31]

Sri Lanka

Prospective study

8 months

IP + OPD

773

> 2 years

Both children and adults

M = 463

F = 310

< 7 days

Reller et al., 2012 [30]

Sri Lanka

Prospective study

8 months

IP + OPD

859

> 2 years

Both children and adults

M = 526

F = 333

< 7 days

Sabchareon et al., 2012 [54]

Thailand

Prospective cohort study

48 months

Community based + IP + OPD

3401

3–15 years

Children

M = 1733

F = 1668

All documented fever with school absenteeism

Suttinont et al., 2006 [12]

Thailand

Prospective observational study in 5 hospitals

12 months

IP

845

> 15 years

Median 38

Adults

M = 661

F = 184

< 15 days

Thompson et al., 2015 [56]

Nepal

Prospective study

38 months

IP + OPD

627

> 2 years

Adults + children

Not specified

UFI

Zaki et al., 2010 [41]

India

Prospective observational study

4 months

IP

602

1 month −12 years

Children

Not specified

< 21 days

Kingston et al., 2018 [38]

Bangladesh

Prospective study

12 months

IP

416

≥12 years

Adults

Not specified

< 21 days

Raina et al., 2018 [32]

India

Cohort study

2 months

IP

1164

> 18 years

Adults

Not specified

≤14 days

Shelke et al., 2017 [33]

India

Prospective cross-sectional

18 months

IP

270

All ages

Adults + children

M = 138

F = 132

< 14 days

Gautam et al., 2019 [57]

Nepal

Cross-sectional study

12 months

IP

1585

> 1 year

Adult + children

M = 728

F = 757

> 4 days

Bodinayake et al., 2018 [35]

Sri Lanka

Prospective study

12 months

IP

976

≥1 years

Adults + children

M = 628

F = 348

≤3 days

Salagre et al., 2017 [55]

India

Prospective observational study

2 months

IP

276

> 13 years

Adults

M = 187

F = 89

AFI

Andrews et al., 2018 [34]

India

Prospective observational study

12 months

IP

1324

> 13 years

Adults

M = 837

F = 487

< 14 days

Wangrangsimakul et al., 2018 [40]

Thailand

Prospective observational study

27 months

IP

200

≥15 years

Adults

M = 114

F = 86

< 21 days

  1. ED Emergency department, IP Inpatients, OPD Outpatient department, M Males, F Females