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Table 3 Characteristics of inpatients with influenza among different age groups during the 2011–2017 and 2017–2018 influenza seasons

From: Clinical characteristics and outcomes during a severe influenza season in China during 2017–2018

Variables n (%)< 14 years14–59 years> = 60 years
2011–2017
(n = 22)
2017–2018
(n = 37)
2011–2017
(n = 81)
2017–2018
(n = 129)
2011–2017
(n = 66)
2017–2018
(n = 123)
Gender-male12 (54.5)16 (43.2)41 (50.6)71 (55.0)49 (74.2)82 (66.7)
Co-morbidities
 Cardiovascular diseases1 (4.5)1 (2.7)17 (21.0)37 (28.7)37 (56.1)82 (66.7)
 Respiratory diseases0 (0)0 (0)3 (3.7)2 (1.6)14 (21.2)22 (17.9)
 Chronic renal diseases0 (0)0 (0)5 (6.2)11 (8.5)6 (9.1)11 (8.9)
 Chronic liver diseases0 (0)0 (0)8 (9.9)14 (10.9)3 (4.5)13 (10.6)
 Diabetes mellitus0 (0)0 (0)5 (6.2)9 (7.0)13 (19.7)20 (16.3)
 Cancer and hematological diseases3 (13.6) 28 (34.6)39 (30.2)25 (37.9)37 (30.1)
 Stroke and Neuromuscular diseases0 (0)0 (0)4 (4.9)2 (1.6)11 (16.7)15 (12.2)
 Immunosuppressant0 (0)0 (0)13 (16.5)21 (16.3)6 (9.1)17 (13.8)
 Pregnancy0 (0)0 (0)0 (0)2 (1.6)0 (0)0 (0)
 Postmortum within 30 days after delivery0 (0)0 (0)0 (0)1 (0.8)0 (0)0 (0)
 Current smoking0 (0)0 (0)7 (8.6)26 (20.2)*13 (19.7)31 (25.2)
 Received seasonal or influenza A (H1N1) vaccination0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)
Symptoms and Lab findings
 Fever (temp > = 38)21 (95.5)37 (100.0)79 (97.5)120 (93.0)59 (89.4)100 (81.3)
 Cough17 (77.3)32 (86.5)64 (79.0)107 (82.9)60 (90.1)108 (87.8)
 Dyspnea0 (0)3 (8.1)6 (7.4)20 (15.5)11 (16.7)27 (22.0)
 Hemoptysis0 (0)0 (0)3 (3.7)9 (7.0)2 (3.0)5 (4.1)
 CNS symptom0 (0)0 (0)1 (1.2)4 (3.1)1 (1.5)7 (5.7)
 WBC < 4 (× 109/L)5 (22.7)8 (21.6)29 (35.8)40 (31.0)16 (24.2)22 (17.9)
 L% < 20%4 (18.2)9 (25.7)51 (63.0)67 (51.9)42 (63.6)86 (69.9)
 Platelet< 100 (× 109/L)1 (4.5)2 (5.4)18 (22.2)22 (17.1)17 (25.8)22 (17.9)
 ALT > 401 (4.5)4 (11.1)20 (24.7)48 (38.1)15 (22.7)34 (29.3)
 AST > 4012 (57.1)22 (64.7)24 (30.0)50 (40.0)18 (27.3)37 (31.4)
 LDH > 30015 (75.0)25 (73.5)19 (33.9)43 (38.4)14 (23.7)40 (37.4)
 CK > 2004 (21.1)10 (29.4)4 (7.1)26 (23.0)*6 (10.2)18 (17.0)
 CRP > 85 (31.3)10 (32.3)60 (81.1)95 (79.8)56 (88.9)91 (82.0)
 ESR > 202 (20.0)4 (25.0)30 (57.7)46 (59.7)35 (85.4)48 (68.6)*
Treatment on admission
 Antibiotics use19 (86.4)30 (81.1)76 (93.8)118 (91.5)65 (98.5)110 (89.4)*
 Mechanical ventilation1 (4.5)0 (0)9 (11.1)13 (10.1)11 (16.7)20 (16.3)
 Oseltamivir8 (36.4)27 (73.0)76 (93.8)99 (76.7)**63 (95.5)96 (78.0)**
 Traditional Chinese Medicine2 (9.1)6 (16.2)15 (18.5)38 (29.5)11 (16.7)20 (16.3)
 Glucocorticoids2 (9.1)7 (18.9)37 (45.7)65 (50.4)25 (37.9)62 (50.4)
Outcome
 In-hospital fatality0 (0)0 (0)1 (1.2)6 (4.7)1 (1.5)13 (10.6)*
  1. WBC white cell (× 109/L), L lymphocyte percent, PLT platelet (× 109/L), ALT alanine aminotransferase (U/L), AST aspartate aminotransferase (U/L), LDH lactate dehydrogenase (U/L), CK creatine kinase (U/L), CRP C-reactive protein (mg/L), ESR erythrocyte sedimentation rate (mm/h), IQR interquartile range
  2. *, ** Boldface values indicate (*P < .05; **P < .01). Comparison of influenza season 2017–2018 with control group (influenza season 2011–2017) among same age groups