Skip to main content

Table 2 Demographics and clinical features of neonates with serotype III GBS invasive infections compared with those with other serotype GBS invasive infections

From: Emerging serotype III sequence type 17 group B streptococcus invasive infection in infants: the clinical characteristics and impacts on outcomes

Clinical characteristics Type III iGBS
(n = 118)
Type Ia iGBS
(n = 33)
Type Ib iGBS
(n = 15)
Type V iGBS
(n = 6)
Other iGBS
(n = 10)
Gestational age (weeks), median (IQR) 39.0 (38.0–40.0) 38.0 (37.0–39.0) 37.0 (30.0–39.0)* 35.5 (29.8–39.3)* 37.0 (34.8–40.0)
Birth body weight (g), median (IQR) 3040 (2700–3350.0) 2760 (2490–3085) 3015 (1350–3165)* 2248 (1586–2912)* 2560 (2016–3138)*
Gender, male/female n (%) 77 (65.3)/41 (34.8) 13 (39.4)/20 (60.6) 8 (53.3)/7 (46.7) 4 (66.7)/2 (33.3) 5 (50.0)/ 5 (50.0)
Onset of diseases (day), median (IQR) 27.5 (14.8–53.3) 30.0 (3.5–56.5) 2.0 (1.0–30.0)* 14.0 (1.0–21.3)* 2.5 (1.0–11.8)*
 Early-onset disease (≤ 7 days) 14 (11.9) 10 (30.3) 10 (66.7)* 2 (33.3) 5 (50.0)
 Late-onset disease (8–90 days) 96 (81.4)* 19 (57.6) 2 (13.3) 2 (33.3) 2 (20.0)
 Late late-onset disease (>  90 days) 8 (6.8) 4 (12.1) 3 (20.0) 2 (33.3) 3 (30.0)
Clinical manifestations
 Bacteremia 115 (97.5) 32 (97.0) 15 (100) 6 (100) 10 (100)
 Meningitis 31 (26.3) 13 (39.4) 6 (40.0) 0 (0) 1 (10.0)
 Pneumonia 12 (10.2) 2 (6.1) 5 (33.3) 0 (0) 2 (20.0)
 Septic shock 8 (6.8) 9 (27.3) 7 (46.7)** 3 (50.0)** 4 (40.0)*
 Respiratory failure 8 (6.8) 8 (24.2) 9 (60.0)** 4 (67.7)** 4 (40.0)*
 Multi-organ failure 2 (1.7) 3 (9.1) 7 (46.7)** 3 (50.0)** 4 (40.0)*
 Disseminated intravascular coagulopathy 5 (4.2) 4 (12.1) 7 (46.7)** 3 (50.0)** 4 (40.0)*
Treatment outcomes
 Complete cure without any sequelae at discharge 104 (88.1) 26 (78.8) 8 (53.3)** 3 (50.0)* 7 (70.0)
 Neurological complications 15 (12.7) 6 (18.2) 2 (13.3) 1 (16.7) 5 (50.0)**
 Mortality 1 (0.8) 3 (9.1) 5 (33.3)** 2 (33.3)** 1 (10.0)
  1. All data were expressed as number (percentage %), unless indicated otherwise
  2. IQR: interquartile range
  3. *P < 0.05 by x2 test with Bonferroni correction
  4. **P < 0.001 by x2 test with Bonferroni correction