Table 1 Characteristics of patients with complement deficiency who developed invasive meningococcal disease in England
From: Invasive meningococcal disease in patients with complement deficiencies: a case series (2008–2017)
Case | Month + year of IMD | Age (years) | Detection method | Capsular group | PorA | Pen MIC | Pen | CtrA cycle number | ACWY Dose 1 | ACWY Dose 2 | 4CMenB Dose 1 | 4CMenB Dose 2 | Eculizumab | Underlying Condition | Antibiotic Prophylaxis |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Jun 2011 | 9 | Culture & PCR | Y | P1.5–1,10–1 | 0.125 | S | 20 | No | Factor D | Penicillin after IMD | ||||
2a | May 2002 | 15 | Culture & PCR | B | N | 0.04 | S | 26 | 2011 | No | C6 deficiency | No, rescue Amoxycillin | |||
2b | Mar 2011 | 24 | Culture & PCR | Y | P1.5–1,10–1 | 0.047 | S | 31 | |||||||
3a | Oct 1989 | 20 | Culture only | Y | NTa | 0.04 | S | 2008 | No | C8 deficiency | Amoxycillin | ||||
3b | Nov 2011 | 42 | Culture only | B | P1.5–2,10–1 | 0.047 | S | ||||||||
4 | Jun 2017 | 15 | PCR only | NGb | No product | NA | NA | 34 | No | No | |||||
5a | Oct 2005 | 4 | PCR only | B | ND | NA | NA | 31 | 2016 | No | C6 deficiency | No | |||
5b | Mar 2018 | 16 | Culture & PCR | Y | P1.5–1,10–1 | 0.064 | S | 36 | |||||||
6 | Mar 2017 | 12 | PCR | Y | P1.5–2,10–2 | NA | NA | 30 | No | C7 deficiency | No | ||||
7 | Mar 2013 | 17 | Culture only | Y | P1.5–1,10–1 | 0.012 | S | No | Hypocomplementaemic urticarial vasculitis (anti-C1q vasculitis) on immunosuppression therapy (diagnosed in 2010) | No | |||||
8 | Apr 2012 | 15 | PCR only | Y | P1.5–1,10–1 | NA | NA | 28 | 2013 | Oct 2014 | Nov 2014 | No | focal glomerulonephritis with persistently low complement C3/C4 (diagnosed in 2012) | Penicillin | |
9 | Oct 2008 | 20 | Culture & PCR | B | P1.17,16–3 | 0.047 | S | 34 | Jul 2008 | Dec 2011 | Jul 2014 | Aug 2014 | Yes | PNH | Penicillin |
10 | Sep 2011 | 20 | Culture only | B | P1.22,14 | 0.25 | S | Aug 2011 | Nov 2014 | Jan 2015 | Yes | PNH | Ciprofloxacin | ||
11 | Jan 2017 | 25 | Culture only | Y | P1.18–1,3 | 0.094 | S | May 2016 | Yes | PNH | Penicillin | ||||
12 | Oct 2009 | 40 | Culture only | B | P1.22,14 | 0.064 | S | Yes | PNH | No | |||||
13 | Mar 2017 | 23 | PCR only | W | P1.5,2 | NA | NA | 26 | Dec 2016 | Yes | PNH | Penicillin | |||
14 | Sep 2015 | 22 | Culture only | NG (B) c | P1.22,14 | 0.50 | R | Mar 2015 | Apr 2015 | May 2015 | Yes (Mar 2015) | Renal | Penicillin | ||
15 | May 2016 | 20 | Culture only | E | P1.5,2 | 0.094 | S | Aug 2011 | Feb 2015 | Apr 2015 | Yes (Oct 2013) | Renal | Not known | ||
16a | Dec 2014 | 20 | PCR only | NG (B)c | P1.7–1,1 | NA | NA | CtrA not detected (but siaD B CT 30) | Apr 2014 | Apr 2014 | May 2014 | Yes (Apr 2014) | Renal | Not known | |
16b | Mar 2017 | 22 | PCR only | NG (B)c | P1.7–1,1 | NA | NA | CtrA not detected (but siaD B CT 31) |