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Table 3 Factors associated with disease progression of nontuberculous mycobacterial lung disease

From: Nontuberculous mycobacterial pulmonary disease diagnosed by two methods: a prospective cohort study

Variables Unadjusted HR (95% CI) Adjusted HR (95% CI)
Age, by each year 0.97 (0.96–0.99) * 0.97 (0.96–0.99) *
Sex, female 1.38 (0.96–2.00)
Body mass index, by 1 kg/m2 0.89 (0.83–0.95) * 0.94 (0.87–1.01)
Smoking
 Never smoker Reference
 Former smoker 0.72 (0.47–1.18)
 Current smoker 1.82 (0.80–4.15)
Haemoglobin, by 1 g/dL 0.83 (0.73–0.95) * 0.89 (0.75–1.06)
Platelet, by 1000/μL 1.00 (1.00–1.01) * 1.00 (1.00–1.00)
Total protein, by 1 g/dL 1.88 (1.22–2.89) * 1.57 (0.97–2.52)
Total bilirubin, by 1 mg/dL 0.40 (0.18–0.85) * 0.42 (0.17–1.04)
SGRQ score, by each score 1.01 (1.00–1.02)
FEV1, by 1 L 1.00 (1.00–1.00)
FVC, by 1 L 1.00 (1.00–1.00)
DLCO, by 1% 0.99 (0.98–1.00) * 0.99 (0.98–1.01)
Computed tomography type
 Nodular bronchiectatic form Reference Reference
 Upper lobe cavitary form 3.69 (2.30–5.94) * 3.16 (1.78–5.62) *
Diagnostic method
 NTM culture on two sputum specimens Reference Reference
 NTM culture on bronchoscopic specimen 0.93 (0.59–1.48) 0.82 (0.48–1.38)
  1. * Indicates statistical significance with P-value< 0.05
  2. Abbreviations: SGRQ St. George’s Respiratory Questionnaire, FEV1 forced expiratory volume in 1 second, FVC forced vital capacity, DLCO diffusing capacity of the lungs for carbon monoxide