Acute kidney injury during daptomycin versus vancomycin treatment in cardiovascular critically ill patients: a propensity score matched analysis

Table 3 Covariate factors associated with AKI development in univariate and stepwise multivariate logistic regression analysis adjusted to the propensity score

	Univariable		Stepwise multivariable
	Odds ratio (95% CI)	p	Adjusted-OR (95% CI)	p
Male sex	4.22 (1.34–13.28)	.014	–	–
Age	1.03 (0.99–1.07)	.075	–	–
Baseline SOFA score	1.26 (1.09–1.44)	.001	–	–
SAPS II score at ICU admission	1.03 (1.00–1.06)	.043	–	–
Baseline creatinine	1.01 (1.00–1.02)	.038	–	–
Vancomycin treatment	6.42 (2.15–19.12)	.001	4.42 (1.39–15.34)	.014

All variables related to AKI (within 7 days after drug initiation) in univariate analysis, defined by p < 0.15 are reported, excepted those resumed in the propensity score. Variables with p ≥ 0.15 were not included into the model. All variables entered into the backward stepwise multivariate model including the propensity score were not independently associated with AKI excepted the treatment with vancomycin. AKI acute kidney injury, SOFA Sepsis-Related Organ Failure Assessment, SAPS Simplified Acute Physiology Score

ISSN: 1471-2334