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Table 1 Clinical characteristics and outcomes comparison in early and late detection groups

From: Time to positivity of blood culture is a risk factor for clinical outcomes in Staphylococcus aureus bacteremia children: a retrospective study

Variables Early Detection Group (n = 14) Late Detection Group
(n = 70)
P
Demographic characteristics
 Age, Median (IQR) 75.00 (16.25–143.50) 49.50 (8.49–124.75) 0.275
 Weight, Median (IQR) 23.00 (8.50–36.25) 14.50 (7.50–32.75) 0.506
 Male (n, %) 11 (78.6%) 44 (62.86%) 0.262
Underlying Conditions
 Hematologic malignancy (n, %) 2 (14.3%) 8 (11.43%) 0.765
 Congenital heart disease (n, %) 4 (28.6%) 10 (14.29%) 0.193
 Neutropenia (n, %) 2 (14.3%) 8 (11.43%) 0.765
 Primary immunodeficiency (n, %) 2 (14.3%) 5 (7.14%) 0.394
 Chronic kidney disease (n, %) 1 (7.1%) 2 (2.86%) 0.433
Source of infection
 Multiple sitesb 5 (35.7%) 19 (27.1%) 0.519
 Pneumonia 3 (21.4%) 20 (28.6%) 0.587
 Bone or joint 0 (0.0%) 13 (18.6%) 0.081
 Skin or soft tissue 0 (0.0%) 9 (12.9%) 0.158
 Primary bacteremia 0 (0.0%) 4 (5.7%) 0.362
 Intravenous catheter 2 (14.3%) 2 (2.9%) 0.068
 Catheter related infectionc 1 (7.1%) 1 (1.4%) 0.203
 Incision 0 (0.0%) 2 (2.9%) 0.525
 Endocarditis 2 (14.3%) 0 (0.0%) 0.001 a
 CNS infection 1 (7.1%) 0 (0.0%) 0.025 a
APACHE II score ≥ 15 (n, %) 5 (35.7%) 22 (31.4%) 0.755
Prior antibiotic exposure (n, %) 7 (50.0%) 28 (40.0%) 0.491
 Appropriate antibiotic exposure (n, %) 1 (7.1%) 12 (17.1%) 0.348
Immunosuppressants use (n, %) 6 (42.9%) 14 (20.0%) 0.068
Nosocomial infection (n, %) 3 (21.4%) 11 (15.7%) 0.603
Methicillin-resistance (n, %) 4 (28.6%) 25 (35.7%) 0.610
Hypoalbuminemia (n, %) 1 ((7.1%) 5 (7.1%) 1.000
Need for Treatments
 Invasive Mechanical ventilation (n, %) 6 (42.9%) 12 (17.1%) 0.033 a
 Vasoactive agent (n, %) 7 (50.0%) 13 (18.6%) 0.012 a
Outcomes
 In-hospital mortality (n, %) 8 (57.1%) 5 (7.1%) 0.000 a
 Septic shock (n, %) 8 (57.1%) 13 (18.6%) 0.002 a
 Length of hospitalization
Median (IQR)
17.00 (2.75–33.00) 22.50 (14.75–37.00) 0.151
  1. ashowed difference in the early and late detection groups (P < 0.05)
  2. b8 cases were bone or joint + skin or soft tissue, 5 cases were bone or joint + skin or soft tissue + pneumonia, 4 cases were skin or soft tissue + pneumonia, 5 cases were bone or joint + pneumonia, 2 cases were endocarditis + pneumonia
  3. cincluding urethral catheters and thoracic drain tube