Table 3 Comparison the diagnostic values between T-SPOT.TB and TST and their combinations
Sensitivity (%, 95CI) | Specificity (%, 95CI) | Positive predictive value (%, 95CI) | Negative predictive value (%, 95CI) | Positive likelihood ratio (95%CI) | Negative likelihood ratio (95%CI) | |
|---|---|---|---|---|---|---|
T-SPOT.TB | 92.9 (64.2–99.6) | 67.3 (52.3–79.6) | 44.8 (27–64) | 97 (82.5–99.8) | 2.84 (1.85–4.36) | 0.11 (0.0160.71) |
TST | 78.6 (48.8–94.3) | 65.3 (50.2–77.9) | 39.2 (22.1–59.3) | 91.4 (75.8–97.8) | 2.26 (1.41–3.63) | 0.32 (0.12–0.91) |
TSPOT.TB and TST (parallel) | 92.9 (64.2–99.6) | 48.9 (34.6–63.5) | 34.2 (20.1–51.4) | 96 (77.7–99.8) | 1.82 (1.33–2.48) | 0.15 (0.02–1.01) |
TSPOT.TB and TST (serial) | 78.5 (48.8–94.3) | 83.7 (69.8–92.2) | 57.8 (34–78.9) | 93.2 (80.3–98.2) | 4.81 (2.41–9.6) | 0.26 (0.09–0.70) |