Table 8 Dynamics of HA and NA glycosylation for H3N2 viruses isolated from MENA region during 2009–2017. In total, glycosylation patterns of 239 HA and 132 NA sequences of H3N2 virus were analyzed. Numbers between brackets represent the percentage of sequences expressing glycosylation sequon in corresponding year while conserved glycosylation sites are indicated in bold
Localization of potential glycosylation sequons in HA and NA of H3N2 viruses | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
HA | ||||||||||||
Amino acid position | ||||||||||||
Year | Number of sequences analyzed | Stem | Head | Stem | ||||||||
2009 | 22 | 8 | 22 | 63 | 126 | 133 | 165 | 246 | 385 | 483 | ||
2011 | 22 | 8 | 22 | 45(23%) | 63 | 126 | 133 | 165 | 246 | 385 | 483 | |
2012 | 37 | 8 | 22 | 45(5%) | 63 | 126 | 133 | 165 | 246 | 385 | 483 | |
2013 | 13 | 8 | 22 | 45(69%) | 63 | 126 | 133 | 165 | 246 | 385 | 483 | |
2014 | 40 | 8 | 22 | 45(92%) | 63 | 126 | 133 | 158(5%) | 165 | 246 | 385 | 483 |
2015 | 47 | 8 | 22 | 45(100%) | 63 | 126 | 133 | 158(81%) | 165 | 246 | 385 | 483 |
2016 | 47 | 8 | 22 | 45(80%) | 63 | 126 | 133 | 158(53%) | 165 | 246 | 385 | 483 |
2017 | 10 | 8 | 22 | 45(100%) | 63 | 126 | 133 | 158(100%) | 165 | 246 | 385 | 483 |
NA | ||||||||||||
Year | Number of sequences analyzed | Amino acid position | ||||||||||
2009 | 5 | 61 | 70 | 86 | 146 | 234 | ||||||
2011 | 22 | 61 | 70 | 86 | 146 | 234 | 367 (90.6%) | |||||
2012 | 32 | 61 | 70 | 86 | 146 | 234 | 367 (100%) | |||||
2013 | 8 | 61 | 70 | 86 | 146 | 234 | 367 (100%) | |||||
2014 | 33 | 61 | 70 | 86 | 146 | 234 | 367 (100%) | |||||
2015 | 23 | 61 | 70 | 86 | 146 | 234 | 367 (100%) | |||||
2016 | 8 | 61 | 70 | 86 | 146 | 234 | 367 (100%) | |||||