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Table 4 Occurrence of grade 3 symptoms, complications, and healthcare use associated with confirmed influenza episodes

From: Epidemiology and burden of influenza in healthy children aged 6 to 35 months: analysis of data from the placebo arm of a phase III efficacy trial

  Confirmed influenza episodes Proportion of episodes
Laboratory-confirmed influenza associated with: N = 263 (%)
Grade 3 symptoms  
 Grade 3 fever a 63 24.3
 ≥ 1 grade 3 influenza-like illness symptom b 8 3.0
Complications  
 Acute otitis media 16 6.1
 Acute lower respiratory infection 23 8.7
 Pneumonia 5 1.9
Medication  
 Any 257 97.7
Antibiotics 109 41.4
 Antipyretic or analgesic medication c 245 93.2
 Antitussives 8 3.0
 Bronchodilators 36 13.7
 Expectorants 10 3.8
 Mucolytic agents 47 17.9
Healthcare use  
 Outpatient visit 150 57.0
 Inpatient hospitalisation 3 1.1
 Intensive care unit admission 0 0.0
  1. a> 39.5 °C for subjects aged < 24 months and ≥ 39.0 °C for subjects aged ≥24 months
  2. bCough, nasal congestion, rhinorrhoea, pharyngitis, otitis, vomiting, or diarrhoea preventing daily activities
  3. cIncludes non-steroidal anti-inflammatory drugs