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Table 5 Comparison of clinical and laboratory outcomes of severe HFMD with prolonged hyperthermia, and/ or neurological manifestations treated with or without IVIG

From: Clinical characteristics and managements of severe hand, foot and mouth disease caused by enterovirus A71 and coxsackievirus A16 in Shanghai, China

Variable IVIG (47)
M (IQR)
Without IVIGa (31)
M (IQR)
Z P
Fever 1 (1,1) 4 (4,4) −9.971 < 0.001
Vomiting 2 (2,2) 3 (3,3) −8.596 < 0.001
Startle 2 (2,2) 3 (3,4) −9.711 < 0.001
Myoclonic twitching 2 (2,2) 4 (3.5,4) −9.483 < 0.001
WBC (> 15 × 109/L) 2 (2,2) 3 (3,3.5) −9.729 < 0.001
CRP (> 40 mg/L) 2 (2,2) 4 (4,4) −10.489 < 0.001
Length of stay (day) 4 (4,5) 5 (5,6) −6.651 < 0.001
  1. Abbreviations: M median, IQR interquartile range, IVIG intravenous gamma globulin intervention. aSubjects with prolonged hyperthermia, and/ or neurological manifestations refused to receive IVIG because of the cost or safety issue
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