The tolerability of single low dose primaquine in glucose-6-phosphate deficient and normal falciparum-infected Cambodians

Table 2 Independent factors associated with several markers of haemoglobin dynamics and recovery in all patients

Parameter	Coefficient	95% confidence interval	P value
Day 7 Day 0 decline in haemoglobin concentration
D0 haemoglobin concentration	−0.34	−0.45– −0.24	< 0.001
D0 parasite count	−2.69 × 10⁻⁷	−4.81 × 10⁻⁶ – −5.60 × 10^− 7	0.014
On DHAPP+ SLDPQ	0.48	0.08–0.88	0.019
Haemoglobin dynamics over 28 days
DHAPP+SLDPQ	0.69	0.11 ─ 1.27	0.019
Age	0.034	0.014–0.055	0.001
Male	0.91	0.19–1.62	0.013
Reticulocyte dynamics	−0.12	− 0.17 – − 0.06	0.000
Total malaria attributable fall in haemoglobin
Treatment failure	−1.28	−2.27 – −0.029	0.012
D7 haemoglobin concentration	−0.53	−0.74 – − 0.32	< 0.001
Male	0.99	0.004–1.99	0.049
Haemoglobin recovery^a
Male	7.2	1.3–40.0	0.025
Age	1.04	1.001–1.08	0.045
D0 haemoglobin concentration	0.51	0.34–0.76	0.001
Reticulocyte dynamics
D0 haemoglobin concentration	−0.320	− 0.420 ─ -0.219	< 0.001

^aBy logistic regression, the odds ratio is reported with 95% confidence interval

ISSN: 1471-2334