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Table 1 Baseline characteristics by treatment arm

From: The tolerability of single low dose primaquine in glucose-6-phosphate deficient and normal falciparum-infected Cambodians

Parameter DHAPP arm N = 53 DHAPP + SLDPQ arm N = 56 P value
Age in years 20 (14–31) [6–76] 24.5 (17.5–32) [4–65] 0.25
Age ≤ 12 y 12 (22.6) 9 (16.1) 0.38
Sex M:F 44:9 44:12 0.56
Occupation
 Farmer 40 (75.5) 46 (83.6) 0.29
Symptoms n = 53 n = 55  
 VAS scorea 2 (2–2) [2, 3] 2 (2–2) [1–3] 0.45
 Fever 52 (98.1) 53 (96.4) 0.58
 Chills 51 (96.2) 53 (96.4) 0.97
 Headache 49 (92.5) 54 (98.2) 0.16
 Anorexia 1 (1.9) 0 (0) 0.31
 Nausea 49 (92.5) 41 (74.6) 0.01
 Vomiting 51 (96.2) 53 (96.4) 0.97
 Abdominal pain 4 (7.6) 4 (7.3) 0.96
 Palpitations 3 (5.7) 9 (16.4) 0.08
 Cough 3 (5.7) 3 (5.5) 0.96
 Muscle aches 4 (7.6) 7 (12.7) 0.37
 Passing normal colour urine 53 (100) 55 (100)
Physical signs
 Temperature 0C 38 (38–38.5) [38–41] 38 (38–38.5) [38–40] 0.75
 Weight kg 48 (36–55) [17–73] 50.5 (40–55.5) [10–74] 0.32
 Respiratory rate / minute 30 (26–30) [20–34] 30 (28–30) [20–32] 0.58
 Normal colour of lips 53 (100) 55 (100)
 Pale conjunctivae/palms/tongue 0 (0) 0 (0)
 Palpable liver 0 (0) 0 (0)
 Palpable spleen 0 (0) 0 (0)
G6PD data    
 G6PD activity median U/g Hb 10.45 (7.9–12.9) [0.4–17.9] 10.15 (6.7–11.7)[0.4–25] 0.23
 G6PD deficient by FSTb 3 (5.7) 6 (10.9) 0.49
 G6PD deficient by RDTc 3 (5.7) 6 (10.9) 0.49
 G6PD Viangchan 3 9 (42.8) 0.69
Haemoglobin electrophoresis n = 52 n = 54  
 Normal haemoglobin 23 (44.2) 28 (51.8) 0.34
 Haemoglobin E 22 (42.3) 19 (35.2)  
 Mixed Hb E alpha thalassemia 3 (5.8) 1 (1.8)  
 Mixed Hb E beta thalassemia 0 3 (5.6)  
 Alpha thalassemia 3 (5.8) 3 (5.6)  
 Heterozygous foetal haemoglobin 1 (1.9) 0  
Full blood count
 Haemoglobin g/dL 12.63 (2.29) [6.9–18.2] 13.19 (2.1) [8.7–18] 0.19
 Reticulocyte count % 1.5 (1–2)[0.4–4.2] 1.65 (1.05–2.6) [0.3–9.2] 0.13
 Methaemoglobin % 1.5 (1.3–1.8) [0.7–1.9] 1.3 (1.2–1.7) [0.6–2] 0.90
 Total white cell count ×  103/μL 5.6 (4.5–7.0) [1.5–13] 5.45 (4.45–6.3) [1.6–10.3] 0.50
Platelet count ×103/μL 89 (49–122) [12–336) 101.5 (76–156.5) [10–328] 0.04
Biochemical parameters
 Total bilirubin μmol/L 15.65 (8.6–19.4) [3.7–56.1] 13.35 (10.1–22.1) [3.7–90.5] 0.87
 Conjugated bilirubin μmol/L 6.35 (4.1–9.2) [1.3–16.7] 5.85 (4.45–9.25) [2.3–20.4] 0.70
 Free bilirubin μmol/L 8.2 (5.2–10.9) [2.2–49.0) 7.4 (5.75–12.5) [1.4–70.1] 0.97
 AST IU/L 26 (22–38) [12–133] 28 (22–38) [15–84] 0.99
 ALT IU/L 21 (16–28) [6–125] 23.5 (15.5–35.5) [4–140] 0.42
LDH IU/L 250 (222–347) [137–772] 225.5 (200–285) [59–657] 0.04
Haptoglobin g/L 0.69 (0.1–1.43) [0.03–2.24] 0.59 (0.1–1.53) [0.01–2.64] 0.60
Creatinine μmol/L 63 (49–74) [29–112] 63.5 (44.5–72) [18–120] 0.53
Parasite data
 Falciparum parasitaemia N/μL 19,800 (5800-68,119) [1–350,000] 18,600 (3923–36,093 [40–800,200] 0.40
Urine
 Hillmen colour scale 3 (3–3) [1–4] 3 (3–3) [1–4] 0.57
  1. a VAS – visual analogue scale from 1 to 5
  2. Continuous data are median (interquartile range) [full range], except the haemoglobin concentration [mean (standard deviation)
  3. Categorical data are n (%)
  4. b Fluorescent spot test
  5. c Rapid diagnostic test
  6. Continuous data are median (interquartile range) [full range], except the haemoglobin concentration: mean (standard deviation) [range]
  7. Categorical data are n (%)
  8. Entries in bold are statistically significant