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Table 2 MIC and cumulative percent inhibited distributions for plazomicin, in relation to the carbapenemase type produced by the 300 K. pneumoniae isolates

From: Nationwide epidemiology of carbapenem resistant Klebsiella pneumoniae isolates from Greek hospitals, with regards to plazomicin and aminoglycoside resistance

Carbapenemase No of isolates No of isolates / (cumulative % of isolates) inhibited at plazomicin MIC (mg/L) of a
≤0.125 0.25 0.5 1 2 4 8 16 32 ≥64b
KPC 200 3
(1.5)
46
(24.5)
46
(47.5)
57
(76.0)
18
(85.0)
11
(90.5)
3
(92.0)
0
(92.0)
0
(92.0)
16
(100)
NDM 50 1
(2.0)
23
(48.0)
13
(74.0)
11
(96.0)
2
(100)
0
(−)
0
(−)
0
(−)
0
(−)
0
(−)
VIM 21 3
(14.3)
3
(28.6)
3
(42.9)
5
(66.7)
1
(71.4)
0
(71.4)
0
(71.4)
0
(71.4)
0
(71.4)
6
(100)
OXA-48 12 1
(8.3)
2
(25.0)
5
(66.7)
2
(83.3)
1
(91.7)
1
(100)
0
(−)
0
(−)
0
(−)
0
(−)
KPC + VIM 14 0
(0.0)
2
(14.3)
0
(14.3)
8
(71.4)
3
(92.9)
1
(100)
0
(−)
0
(−)
0
(−)
0
(−)
NDM + OXA-48 2 0
(0.0)
2
(100)
0
(−)
0
(−)
0
(−)
0
(−)
0
(−)
0
(−)
0
(−)
0
(−)
KPC + OXA-48 1 0
(0.0)
0
(0.0)
0
(0.0)
0
(0.0)
0
(0.0)
0
(0.0)
0
(0.0)
0
(0.0)
0
(0.0)
1
(100)
All 300 8
(2.7)
78
(28.7)
67
(51.0)
83
(78.7)
25
(87.0)
13
(91.3)
3
(92.3)
0
(92.3)
0
(92.3)
23
(100)
  1. a The MIC inhibiting 90% of isolates (MIC90) is bolded
  2. b All isolates (n = 23) with plazomicin MIC ≥64 mg/L harbored a 16S rRNA methylase gene