Severe fever with thrombocytopenia syndrome: comparison with scrub typhus and clinical diagnostic prediction

BMC Infectious Diseases

Table 3 Laboratory findings at the initial presentation (n = 362)

Variable	Scrub typhus (n = 255)				SFTS	P value^c
	Eschar-positive	P value^a	Eschar-negative	P value^b	n = 107
	n = 205	P value^a	n = 50	P value^b	n = 107
White blood cells, /mm³	6909 ± 3755	< 0.001	8426 ± 4207	< 0.001	2317 ± 1930	< 0.001
Leukopenia (< 4000/mm³), %	42 (20.5)	< 0.001	5 (10.0)	< 0.001	97/106 (91.5)	< 0.001
Hemoglobin, g/dL	12.8 ± 1.8	0.007	12.1 ± 1.6	< 0.001	13.4 ± 1.7	0.001
Anemia (< 11 g/dL)	22 (10.7)	0.532	11 (22.0)	0.019	9/106 (8.5)	0.230
Platelet (×10³/mm³)	133 ± 47	< 0.001	161 ± 89	< 0.001	61 ± 30	< 0.001
Thrombocytopenia^d, %	21 (10.2)	< 0.001	5 (10.0)	< 0.001	83/106 (78.3)	< 0.001
Serum albumin, d/dL	3.5 ± 0.6	0.575	3.07 ± 0.59	0.031	3.4 ± 0.6	0.851
Total bilirubin, mg/dL	0.93 ± 1.14	< 0.001	0.64 ± 0.66	0.034	0.40 ± 0.61	< 0.001
AST, IU/L	108 ± 107	< 0.001	170 ± 277	0.007	381 ± 505	< 0.001
≥ 400 IU/L	4/204 (2.0)	< 0.001	4 (8.0)	0.001	33/106 (31.1)	< 0.001
ALT, IU/L	96 ± 108	0.026	138 ± 192	0.824	131 ± 159	0.135
≥ 200 IU/L	16/204 (7.8)	0.002	9 (18.0)	0.789	21/106 (19.8)	0.010
Lactate dehydrogenase, IU/L	700 ± 423	< 0.001	761 ± 393	0.014	1615 ± 2159	< 0.001
≥ 800 IU/L	48/183 (26.2)	< 0.001	14/40 (35.0)	0.021	55/97 (56.7)	< 0.001
Serum creatinine, mg/dL	1.04 ± 0.63	0.634	1.14 ± 0.70	0.567	1.08 ± 0.51	0.841
≥ 2.0 mg/dL	5/203 (2.5)	1.000	4 (8.0)	0.086	2/105 (1.9)	0.519
Hypokalemia (< 3.5 mmol/L)	52/204 (25.5)	0.155	12/49 (24.5)	0.372	19/104 (18.3)	0.153
C-reactive protein, mg/dL	7.27 ± 5.50	< 0.001	9.82 ± 7.41	< 0.001	1.24 ± 2.64	< 0.001
< 1 mg/dL	7/182 (3.8)	< 0.001	1/49 (2.0)	< 0.001	66/102 (64.7)	< 0.001

Abbreviations: SFTS severe fever with thrombocytopenia syndrome, AST aspartate aminotransferase, ALT alanine aminotransferase
^aP value when compared to SFTS
^bP value when compared to SFTS
^cP value when compared to all scrub typhus
^dThrombocytopenia, < 80 × 10³ /mm³

ISSN: 1471-2334