Fig. 2
From: Immune signatures for HIV-1 and HIV-2 induced CD4+T cell dysregulation in an Indian cohort
Level of Immune activation in HIV-1 and HIV-2 chronic infection. a Comparison of expression of immune activation markers (CD38&HLA-DR) on CD4+T and CD8+T cells among ART-naïve HIV-1 (n = 11), HIV-2 (n = 13) infected individuals and seronegative individuals (n = 11). Statistical significance was evaluated by unpaired t test; *, p < 0.05; **, p < 0.01; and ***, p < 0.001. The frequencies of activated cells are those observed within CD4+T and CD8+T cell gates as outlined in Additional file 4 Figure S4. b Correlation analysis between frequency of CD4+ and CD8+ activated T cells and Tregs cells in both ART-naïve HIV-1(n = 11) and HIV-2 (n = 13) infected individuals. Spearman’s correlation test was used to determine the correlation coefficient (r) and the significance (p < 0.05).