Unusual manifestation of disseminated herpes simplex virus type 2 infection associated with pharyngotonsilitis, esophagitis, and hemophagocytic lymphohisitocytosis without genital involvement

Kurosawa, Shuhei; Sekiya, Noritaka; Fukushima, Kazuaki; Ikeuchi, Kazuhiko; Fukuda, Akito; Takahashi, Hideyuki; Chen, Fangyi; Hasegawa, Hideki; Katano, Harutaka; Hishima, Tsunekazu; Setoguchi, Keigo

doi:10.1186/s12879-019-3721-0

Table 1 Adult disseminated HSV-2 infection: 15 reported cases and the presented case

From: Unusual manifestation of disseminated herpes simplex virus type 2 infection associated with pharyngotonsilitis, esophagitis, and hemophagocytic lymphohisitocytosis without genital involvement

Year, author [reference]	Age (y)/Sex	Underlying condition or disease	Immunosuppressive therapy at the onset	Infected organs	Complications	Treatment	Outcome
2005, Yamaguchi K et al. [11]	N/A / F	Pregnancy	None	Genital, skin	HLH	ACV	Survived
2006, Czartoski T et al. [12]	28 / F	Immunocompetent	None	Liver, skin	Candidemia	ACV	Died
2006, Ramasamy K et al. [13]	33 / M	Bone marrow failure of unknown etiology	Oxymetholone, prednisolone	Skin	HLH, rhabdomyolysis	ACV	Died
2007, Abbo L et al. [14]	51 / M	Immunocompetent	None	Liver, colon	FHF	ACV	Died
2010, Peppercorn A et al. [15]	58 / M	Burn	None	Skin, liver, lung	Septic shock	BSC	Dead
2012, Lee L et al. [16]	24 / F	AIDS	None	Pharynx, genital	None	ACV	Survived
2015, Rimawi BH et al. [17]	25 / F	Immunocompetent	None	Liver, skin, genital	None	ACV	Survived
2015, Rimawi BH et al. [17]	24 / F	Immunocompetent	None	Liver, skin	None	ACV	Survived
2015, Rimawi BH et al. [17]	27 / F	Pregnancy	None	Liver, genital	None	ACV	Survived
2015, Erdmann N et al. [18]	22 / M	Atopic dermatitis	Systemic corticosteroids	Skin, genital	None	ACV	Survived
2016, Down C et al. [19]	67 / M	Prostate cancer	None	Liver, genital	Ireus	ACV	Survived
2016, Ikumi K et al. [20]	56 / M	Muscle sclerosis	Methylprednisolone pulse therapy	Liver, rectum, adrenal grand etc.	HLH	None	Died
2017, Natu A et al. [21]	23 / M	Crohn’s disease	Vedolizumab, prednisolone	Liver, mouth, genital	Crohn’s flare	ACV	Survived
2017, Natu A et al. [21]	18 / F	Pregnancy	None	Liver	Septic shock, FHF	ACV	Died
2017, Natu A et al. [21]	65 / F	Liver cirrhosis	Liver transplantation	Liver	None	ACV	Survived
Presented case	46 / M	Hypereosinophilic syndrome	Azathioprine, prednisolone	Tonsil, esophagus,skin	HLH	ACV	Survived

Abbreviations: ACV acyclovir, AIDS acquired immune deficiency syndrome, BSC best supportive care, M male, F female, FHF fulminant hepatic failure, HLH hemophagocytic lymphohistiocytosis, y year

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ISSN: 1471-2334

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