Table 1 Molecular characteristics of clinical fluconazole non-susceptible Candida spp. blood isolates
From: Molecular mechanisms of azole resistance in Candida bloodstream isolates
Isolate reference | MIC, ug/mL | Gene expression (fold increase) | Erg11p amino acid substitution(s) | ||||||
|---|---|---|---|---|---|---|---|---|---|
FLC | VRC | POS | ERG11 | CDR1 | CDR2 | MDR1 | |||
C. albicans | CW138 | 4 (SDD) | 0.12 (S) | 0.25 (NWT) | 0.41 | 1.60 | 9.01 | 0.18 | A114S, Y257H |
CW357 | 4 (SDD) | 0.25 (SDD) | 0.25 (NWT) | 0.18 | 1.08 | 5.79 | 0.15 | A114S, Y257H | |
CW241 | 128 (R) | 4 (R) | 1 (NWT) | 0.58 | 4.49 | 122.50 | 141.28 | A114S, Y257H | |
CW216 | 128 (R) | ≥8 (R) | ≥8 (NWT) | 0.15 | 0.79 | 3.32 | 4.86 | E266D, V488I | |
C. glabrata | CW193 | 64 (R) | 4 (NWT) | ≥8 (NWT) | 0.46 | 23.12 | 23.24 | N.A. | None |
CW262 | 64 (R) | 0.25 (WT) | 0.5 (WT) | 1.08 | 22.45 | 7.13 | N.A. | I166S | |
CW378 | 64 (R) | 4 (NWT) | 2 (WT) | 0.56 | 4.02 | 8.08 | N.A. | None | |
CW088 | ≥256 (R) | 4 (NWT) | ≥8 (NWT) | 1.10 | 19.78 | 14.55 | N.A. | None | |
CW404 | ≥256 (R) | ≥8 (NWT) | ≥8 (NWT) | 0.29 | 18.70 | 6.92 | N.A. | I166S | |
C. tropicalis | CW190 | 4 (SDD) | 0.25 (SDD) | 0.5 (NWT) | 0.39 | 6.11 | N.A. | 0.47 | None |
CW219 | 4 (SDD) | 0.5 (R) | 0.5 (NWT) | 0.95 | 1.56 | N.A. | 0.77 | None | |
CW361 | 4 (SDD) | 0.5 (R) | 0.25 (NWT) | 2.38 | 0.27 | N.A. | 0.01 | None | |
CW395 | 4 (SDD) | 0.5 (R) | 0.5 (NWT) | 0.45 | 0.63 | N.A. | 3.27 | None | |
CW071 | 8 (R) | 0.25 (SDD) | 0.5 (NWT) | 0.11 | 1.28 | N.A. | 30.53 | None | |
CW018 | 16 (R) | 0.25 (SDD) | 0.25 (NWT) | 0.61 | 2.75 | N.A. | 23.42 | Y132F, S154F | |
CW107 | 16 (R) | 1 (R) | 0.5 (NWT) | 0.36 | 0.09 | N.A. | 7.12 | Y132F, S154F | |
CW178 | 16 (R) | 0.5 (R) | 1 (NWT) | 2.83 | 3.81 | N.A. | 0.64 | None | |
CW385 | 16 (R) | 0.5 (R) | 1 (NWT) | 0.12 | 4.43 | N.A. | 2.93 | None | |
CW263 | 64 (R) | 4 (R) | 0.12 (NWT) | 4.45 | 1.95 | N.A. | 1.44 | Y132F, S154F | |
CW386 | 128 (R) | 2 (R) | 4 (NWT) | 1.36 | 0.68 | N.A. | 1.33 | None | |
CW065 | ≥256 (R) | 4 (R) | 0.5 (NWT) | 1.04 | 1.30 | N.A. | 23.07 | Y132F, S154F | |
CW067 | ≥256 (R) | ≥8 (R) | 1 (NWT) | 0.11 | 0.93 | N.A. | 7.04 | Y132F, S154F, F145 L | |
CW192 | ≥256 (R) | ≥8 (R) | 1 (NWT) | 1.36 | 0.76 | N.A. | 0.52 | Y132F, S154F | |
CW242 | ≥256 (R) | ≥8 (R) | 1 (NWT) | 0.50 | 6.10 | N.A. | 1.21 | Y132F, S154F | |
CW266 | ≥256 (R) | 4 (R) | 0.25 (NWT) | 0.27 | 10.08 | N.A. | 1.59 | None | |
CW271 | ≥256 (R) | ≥8 (R) | 1 (NWT) | 7.47 | 1.30 | N.A. | 0.31 | Y132F, S154F | |