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Table 1 Molecular characteristics of clinical fluconazole non-susceptible Candida spp. blood isolates

From: Molecular mechanisms of azole resistance in Candida bloodstream isolates

Isolate reference MIC, ug/mL Gene expression (fold increase) Erg11p amino acid substitution(s)
FLC VRC POS ERG11 CDR1 CDR2 MDR1  
C. albicans CW138 4 (SDD) 0.12 (S) 0.25 (NWT) 0.41 1.60 9.01 0.18 A114S, Y257H
CW357 4 (SDD) 0.25 (SDD) 0.25 (NWT) 0.18 1.08 5.79 0.15 A114S, Y257H
CW241 128 (R) 4 (R) 1 (NWT) 0.58 4.49 122.50 141.28 A114S, Y257H
CW216 128 (R) ≥8 (R) ≥8 (NWT) 0.15 0.79 3.32 4.86 E266D, V488I
C. glabrata CW193 64 (R) 4 (NWT) ≥8 (NWT) 0.46 23.12 23.24 N.A. None
CW262 64 (R) 0.25 (WT) 0.5 (WT) 1.08 22.45 7.13 N.A. I166S
CW378 64 (R) 4 (NWT) 2 (WT) 0.56 4.02 8.08 N.A. None
CW088 ≥256 (R) 4 (NWT) ≥8 (NWT) 1.10 19.78 14.55 N.A. None
CW404 ≥256 (R) ≥8 (NWT) ≥8 (NWT) 0.29 18.70 6.92 N.A. I166S
C. tropicalis CW190 4 (SDD) 0.25 (SDD) 0.5 (NWT) 0.39 6.11 N.A. 0.47 None
CW219 4 (SDD) 0.5 (R) 0.5 (NWT) 0.95 1.56 N.A. 0.77 None
CW361 4 (SDD) 0.5 (R) 0.25 (NWT) 2.38 0.27 N.A. 0.01 None
CW395 4 (SDD) 0.5 (R) 0.5 (NWT) 0.45 0.63 N.A. 3.27 None
CW071 8 (R) 0.25 (SDD) 0.5 (NWT) 0.11 1.28 N.A. 30.53 None
CW018 16 (R) 0.25 (SDD) 0.25 (NWT) 0.61 2.75 N.A. 23.42 Y132F, S154F
CW107 16 (R) 1 (R) 0.5 (NWT) 0.36 0.09 N.A. 7.12 Y132F, S154F
CW178 16 (R) 0.5 (R) 1 (NWT) 2.83 3.81 N.A. 0.64 None
CW385 16 (R) 0.5 (R) 1 (NWT) 0.12 4.43 N.A. 2.93 None
CW263 64 (R) 4 (R) 0.12 (NWT) 4.45 1.95 N.A. 1.44 Y132F, S154F
CW386 128 (R) 2 (R) 4 (NWT) 1.36 0.68 N.A. 1.33 None
CW065 ≥256 (R) 4 (R) 0.5 (NWT) 1.04 1.30 N.A. 23.07 Y132F, S154F
CW067 ≥256 (R) ≥8 (R) 1 (NWT) 0.11 0.93 N.A. 7.04 Y132F, S154F, F145 L
CW192 ≥256 (R) ≥8 (R) 1 (NWT) 1.36 0.76 N.A. 0.52 Y132F, S154F
CW242 ≥256 (R) ≥8 (R) 1 (NWT) 0.50 6.10 N.A. 1.21 Y132F, S154F
CW266 ≥256 (R) 4 (R) 0.25 (NWT) 0.27 10.08 N.A. 1.59 None
CW271 ≥256 (R) ≥8 (R) 1 (NWT) 7.47 1.30 N.A. 0.31 Y132F, S154F
  1. FLC Fluconazole, VRC Voriconazole, POS Posaconazole, S Susceptible, SDD Susceptible dose-dependent, R Resistant, WT Wild-type, NWT Non wild-type, values in bold represent gene overexpression; underlined values represent heterozygous substitutions