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Table 4 Multivariate analysis on the incidence of fungal infection

From: Effect of laminar air flow and building construction on aspergillosis in acute leukemia patients: a retrospective cohort study

variables

Adjusted HR with model 1a

p value

Adjusted HR with model 2b

p value

Neutropenia

0.74

0.647

  

treatment periodc

 before construction (phase A)

1.32

0.698

1.21

0.790

 during construction (phase B)

2.75

0.163

2.82

0.140

 the late period after moving (phase D)

4.63

0.010

4.64

0.008

antifungal prophylaxisd

1.40

0.702

1.41

0.430

ALL vs AML

0.59

0.423

0.62

0.470

age

1.19

0.717

1.23

0.660

  1. AML denotes acute myelogenous leukemia; ALL acute lymphoblastic leukemia, HR hazard ratio
  2. aModel 1 is a Cox proportional hazards ratio with time-dependent covariates
  3. bModel 2 is a Fine and Gray proportional hazard regression model
  4. cHR is calculated by comparison of the incidence in each period with in the early period after moving
  5. dHR is the ratio of the incidence in patients who received fluconazole with mold-active agent prophylaxis with the incidence in patients who received fluconazole-only prophylaxis