Human adenovirus type 7 infection causes a more severe disease than type 3

BMC Infectious Diseases

Table 1 Demographic and clinical characteristic of children with HAdV-3 and HAdV-7 of admission, 2009-2015

Characteristic	HAdV-3	HAdV-7	p
Characteristic	(n = 127)	(n = 131)	p
Age(years)
≤ 2 years	91 (71.7)	83 (63.4)	0.155
> 2 years	36 (28.3)	48 (36.6)
Gender
Male/female	85/42	90/41	0.761
Underlying diseases	26 (20.5)	24 (18.3)	0.753
Coinfection	73 (57.5)	53 (40.5)	0.851
Symptom, signs
Cough	118 (92.9)	124 (94.7)	0.974
Fever	89 (70.1)	112 (85.5)	0.656
Peak temperature (> 39)	27 (21.3)	25 (19.1)	0.953
Wheezing	50 (39.4)	89 (32.1)	0.220
Croup	50 (39.4)	42 (32.1)	0.681
Dyspnea	19 (15.0)	31 (23.7)	0.077
Dry rales	57 (44.9)	53 (40.5)	0.627
Moist rales	87 (68.5)	101 (77.1)	0.763
Seizure	1 (0.8)	2 (1.5)	1.000
Diagnosis
PCF	1 (0.8)	1 (0.8)	1.000
URTI	3 (2.4)	3 (2.3)	1.000
Bronchitis	2 (1.6)	6 (4.6)	0.279
Pneumonia	121 (95.3)	121 (92.4)	0.958
Complication
Pleural effusion	2 (1.6)	6 (4.6)	0.279
Severe pneumonia	21 (16.5)	41 (31.3)	0.005^a
Respiratory failure	19 (15.0)	36 (27.5)	0.015^a
ARDS	0	1 (0.8)	1.000
Suspicious BO	1 (0.8)	2 (1.5)	1.000
Intracranial infection	1 (0.8)	4 (3.1)	0.369
Toxic encephalopathy	1 (0.8)	25 (19.1)	0.0001^a
Outcomes
Hospitalization days	7.7 ± 0.7	8.2 ± 0.6	0.031^a
ICU admission	2 (1.6)	6 (4.6)	0.279

Note: Underlining diseases include premature birth, congenital heart disease, asthma, eczema and tuberculosis
Coinfection with influenza viruses, RSV, PIV, MPV, HRV, COV and HBoV
The numbers in brackets represent the percentage of positive cases
Bold Abbreviations: PCF pharyngo conjunctival fever, URTI upper respiratory tract infection, ICU intensive care unit, BO Bronchiolitis obliterans, not determined, ARDS acute respiratory distress syndrome
P-values indicate comparisons with significance differences (P ≤ 0.05)
“^a”: a significant difference between two groups

ISSN: 1471-2334