Fig. 4

Phylogenetic analysis of HIV-1 genes encoding protease and reverse transcriptase residues. HIV-1197-bp and 720-bp long sequences of genes encoding, respectively, protease and reverse transcriptase were analyzed. Red circles and boxes indicate patients in the high IFN-γ group. Blue circles indicate patients in the high IL-6 group. Sequences from four patients, indicated by red boxes, had an insertion of the amino acid sequence Q[S/N]RPE in the p6 region of gag and an addition of the amino acid sequence QNME in the C′-terminus of integrase. Sequences from six patients, including these four patients, formed a cluster with a bootstrapping value of 84.8%, and the details are shown in the inset