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Table 4 Factors associated with death during hospitalization

From: Mortality in hospitalized patients with tuberculous meningitis

  Surviving (n = 183) Deceased (n = 80) Bivariable Analysis Multivariable Analysis
RR 95% CI p RR 95% CI p
Male 134 (73.2%) 57 (71.2%) 0.93 0.63–1.40 0.740 0.79 0.54–1.13 0.201
Age > 40 years old 53 (28.9%) 36 (45%) 1.59 1.12–2.29 0.010 1.64 1.16–2.29 0.004
HIV Infection 58 (31.7%) 42 (52.5%) 1.80 1.25–2.60 0.001 2.06 1.44–2.94 < 0.001
History of tuberculosis 40 (21.9%) 23 (28.8%) 1.28 0.84–1.90 0.217    
Alcoholism / Drug addiction 40 (21.9%) 20 (25.0%) 1.13 0.74–1.71 0.572    
Glasgow < 14 86 (48.9%) 60 (77.3%) 2.30 1.58–3.48 < 0.001 2.08 1.38–2.75 < 0.001
Focal Neurologic deficits 56 (31.8%) 35 (45.5%) 1.48 1.03–2.14 0.036 1.14 0.79–1.64 0.473
BMRC II 90 (49.2%) 43 (53.8%) 1.88 1.13–3.13 0.015 1.78 1.07–2.97 0.027
BMRC III 16 (8.74%) 21 (26.3%) 3.30 1.94–5.59 < 0.001 3.11 1.78–5.45 < 0.001
ADA > 9 UI/L 87 (51.8%) 43 (57.3%) 1.17 0.80–1.71 0.426    
MDR-TB 4 (16.7%) 4 (20.0%) 1.08 0.50–2.39 0.833    
CSF Positive culture 34 (18.6%) 34 (42.5%) 2.11 1.50–3.00 < 0.001 1.95 1.38–2.75 < 0.001
Tuberculosis outside CNS 53 (39.3%) 22 (52.3%) 1.43 0.95–2.15 0.086