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Table 4 Univariate and fitted estimates of covariates included in the time-dependent Cox proportional hazard models on the risk of blood stream infection and mortality, including variables confined by the modified comorbidity index

From: Risk of death after first-time blood stream infection in incident dialysis patients with specific consideration on vascular access and comorbidity

Model entry

Variable

Univariate HR

P Value

Fitted HR

P value

Univariate HR

P Value

Fitted HR

P Value

  

Blood stream infection

Mortality

RRT initiation

AVF*

1.29

0.016

1.37

0.003

0.97

0.745

0.90

0.223***

TC*

2.29

< 0.001

2.25

< 0.001

1.75

< 0.001

1.48

< 0.001

NTC*

7.53

< 0.001

6.92

< 0.001

6.20

< 0.001

5.19

< 0.001

Sex

1.06

NS

–

–

0.98

NS

–

–

Age 50–59**

1.14

NS

–

–

1.75

0.001

1.65

0.004

Age 60–69**

1.05

NS

–

–

2.56

< 0.001

2.20

< 0.001

Age > 70**

1.01

NS

–

–

4.77

< 0.001

3.70

< 0.001

Heart Failure

1.30

0.003

–

–

2.05

< 0.001

1.34

< 0.001

AMI

1.20

0.068

–

–

1.92

< 0.001

1.23

0.013

Vascular

1.13

NS

–

–

1.78

< 0.001

1.25

0.002

CNS disease

0.96

NS

–

–

1.45

< 0.001

1.14

0.079

COPD

1.18

0.094

–

–

1.79

< 0.001

1.34

< 0.001

Collagenoses

0.98

NS

–

–

1.02

NS

0.84

0.122

Peptic ulcer

1.25

0.039

–

–

1.48

< 0.001

–

–

Liver disease

1.76

< 0.001

1.52

0.005

1.36

0.028

1.41

0.016

Cancer

1.18

0.072

–

–

1.81

< 0.001

1.35

< 0.001

Diabetes

1.34

< 0.001

1.30

< 0.001

1.30

< 0.001

1.22

0.003

Post BSI

AVF*

1.14

0.720

0.98

0.947

0.76

0.252

0.88

0.627 ***

TC*

2.38

0.025

1.67

0.195

1.25

0.416

1.66

0.086

NTC*

3.86

0.002

2.36

0.022

3.19

< 0.001

3.58

< 0.001

Sex

1.13

NS

–

–

1.30

0.037

–

–

Age 50–59**

1.57

0.096

–

–

1.49

NS

1.70

0.093

Age 60–69**

1.26

NS

–

–

2.66

< 0.001

2.81

< 0.001

Age > 70**

1.50

NS

–

–

6.13

< 0.001

6.11

< 0.001

Heart Failure

1.54

0.020

–

–

1.82

< 0.001

1.43

0.010

AMI

1.40

NS

–

–

1.80

< 0.001

–

–

Vascular

1.11

NS

–

–

1.71

< 0.001

–

–

CNS disease

1.11

NS

–

–

1.43

0.008

–

–

COPD

1.07

NS

–

–

1.25

NS

–

–

Collagenosis

1.98

0.003

1.58

0.050

0.78

NS

–

–

Peptic ulcer

2.00

< 0.001

1.73

0.005

1.43

0.017

–

–

Liver disease

1.94

0.007

1.82

0.021

1.39

NS

2.23

< 0.001

Cancer

1.62

0.009

1.36

0.115

2.30

< 0.001

1.64

< 0.001

Diabetes

1.44

0.019

1.46

0.024

0.97

NS

–

–

Gram pos

0.84

NS

–

–

0.68

0.003

0.80

0.100

  1. AMI acute myocardial infarction, CNS central nerve system, COPD chronic obstructive pulmonary disease, HD hemodialysis, AVF arteriovenous fistula, TC tunneled catheter, NTC non-tunneled catheter, NS not significant, HR hazard ratio, CI confidence interval
  2. *Analyzed as a four-leveled variable with peritoneal dialysis as reference
  3. **Analyzed as a four-leveled variable with ‘age < 50 years’ as reference
  4. ***Included in the model as the overall P-value for the four-leveled variable was < 0.15
  5. - did not meet the significance levels for final assessments in the fitted models
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BMC Infectious Diseases

ISSN: 1471-2334

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