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Table 4 Univariate and fitted estimates of covariates included in the time-dependent Cox proportional hazard models on the risk of blood stream infection and mortality, including variables confined by the modified comorbidity index

From: Risk of death after first-time blood stream infection in incident dialysis patients with specific consideration on vascular access and comorbidity

Model entry Variable Univariate HR P Value Fitted HR P value Univariate HR P Value Fitted HR P Value
   Blood stream infection Mortality
RRT initiation AVF* 1.29 0.016 1.37 0.003 0.97 0.745 0.90 0.223***
TC* 2.29 < 0.001 2.25 < 0.001 1.75 < 0.001 1.48 < 0.001
NTC* 7.53 < 0.001 6.92 < 0.001 6.20 < 0.001 5.19 < 0.001
Sex 1.06 NS 0.98 NS
Age 50–59** 1.14 NS 1.75 0.001 1.65 0.004
Age 60–69** 1.05 NS 2.56 < 0.001 2.20 < 0.001
Age > 70** 1.01 NS 4.77 < 0.001 3.70 < 0.001
Heart Failure 1.30 0.003 2.05 < 0.001 1.34 < 0.001
AMI 1.20 0.068 1.92 < 0.001 1.23 0.013
Vascular 1.13 NS 1.78 < 0.001 1.25 0.002
CNS disease 0.96 NS 1.45 < 0.001 1.14 0.079
COPD 1.18 0.094 1.79 < 0.001 1.34 < 0.001
Collagenoses 0.98 NS 1.02 NS 0.84 0.122
Peptic ulcer 1.25 0.039 1.48 < 0.001
Liver disease 1.76 < 0.001 1.52 0.005 1.36 0.028 1.41 0.016
Cancer 1.18 0.072 1.81 < 0.001 1.35 < 0.001
Diabetes 1.34 < 0.001 1.30 < 0.001 1.30 < 0.001 1.22 0.003
Post BSI AVF* 1.14 0.720 0.98 0.947 0.76 0.252 0.88 0.627 ***
TC* 2.38 0.025 1.67 0.195 1.25 0.416 1.66 0.086
NTC* 3.86 0.002 2.36 0.022 3.19 < 0.001 3.58 < 0.001
Sex 1.13 NS 1.30 0.037
Age 50–59** 1.57 0.096 1.49 NS 1.70 0.093
Age 60–69** 1.26 NS 2.66 < 0.001 2.81 < 0.001
Age > 70** 1.50 NS 6.13 < 0.001 6.11 < 0.001
Heart Failure 1.54 0.020 1.82 < 0.001 1.43 0.010
AMI 1.40 NS 1.80 < 0.001
Vascular 1.11 NS 1.71 < 0.001
CNS disease 1.11 NS 1.43 0.008
COPD 1.07 NS 1.25 NS
Collagenosis 1.98 0.003 1.58 0.050 0.78 NS
Peptic ulcer 2.00 < 0.001 1.73 0.005 1.43 0.017
Liver disease 1.94 0.007 1.82 0.021 1.39 NS 2.23 < 0.001
Cancer 1.62 0.009 1.36 0.115 2.30 < 0.001 1.64 < 0.001
Diabetes 1.44 0.019 1.46 0.024 0.97 NS
Gram pos 0.84 NS 0.68 0.003 0.80 0.100
  1. AMI acute myocardial infarction, CNS central nerve system, COPD chronic obstructive pulmonary disease, HD hemodialysis, AVF arteriovenous fistula, TC tunneled catheter, NTC non-tunneled catheter, NS not significant, HR hazard ratio, CI confidence interval
  2. *Analyzed as a four-leveled variable with peritoneal dialysis as reference
  3. **Analyzed as a four-leveled variable with ‘age < 50 years’ as reference
  4. ***Included in the model as the overall P-value for the four-leveled variable was < 0.15
  5. - did not meet the significance levels for final assessments in the fitted models