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Table 4 The difference of drug susceptibility between Beijing genotype family and non-Beijing genotype family when considered first-line drug resistance (n = 1189)

From: Characterization of Mycobacterium tuberculosis strains in Beijing, China: drug susceptibility phenotypes and Beijing genotype family transmission

Characteristic

Category

Total

New cases

Retreated cases

Number of reported cases

Beijing family (%)

Non-Beijing family (%)

OR (95% CI)

p value

Number of reported cases

Beijing family (%)

Non-Beijing family (%)

OR (95% CI)

p value

Number of reported cases

Beijing family (%)

Non-Beijing family (%)

OR (95% CI)

p value

All

 

1189

990

199

  

1065

885

180

  

124

105

19

  

DST profile

Pansusceptible

849

710(71.7)

139(69.9)

1.027(0.930–1.134)

0.325

800

667(75.4)

133(73.9)

1.020(0.928–1.121)

0.348

49

43(41)

6(31.6)

1.297(0.644–2.613)

0.221

 

INH

205

161(16.3)

44(22.1)

0.736(0.547–0.989)

0.032

141

110(12.4)

31(17.2)

0.722(0.501–1.040)

0.042

64

51(48.6)

7(36.9)

1.318(0.709–2.453)

0.173

 

RIF

119

99(10)

20(10.1)

0.995(0.631–1.569)

0.534

64

53(6)

11(6.1)

0.980(0.522–1.839)

0.475

55

46(43.8)

9(47.4)

0.925(0.549–1.557)

0.337

 

SM

226

185(18.7)

41(20.6)

0.907(0.670–1.227)

0.295

176

143(16.2)

33(18.3)

0.881(0.625–1.242)

0.237

50

42(40)

8(42.1)

0.950(0.534–1.692)

0.431

 

EMB

161

129(13)

32(16.1)

0.810(0.568–1.157)

0.151

117

92(10.4)

25(13.9)

0.748(0.496–1.130)

0.086

44

37(35.2)

7(36.9)

0.956(0.503–1.820)

0.447

 

MDR

107

88(8.9)

19(9.6)

0.931(0.581–1.492)

0.427

58

48(5.4)

10(5.6)

0.976(0.503–1.893)

0.473

49

40(38.1)

9(47.4)

0.804(0.472–1.370)

0.224

  1. INH Isoniazid, LFP Rifampicin; SM Streptomycin; EMB Ethambutol; MDR multi-drug resistance
  2. p value indicates whether there is a significant difference between Beijing family and non-Beijing family (p < 0.05 represents a statistically significant difference)