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Table 2 Bivariate analysis of the factors associated with treatment initiation in adult patients with nontuberculous mycobacterial lung disease without systemic immunodeficiency

From: A retrospective study of factors associated with treatment decision for nontuberculous mycobacterial lung disease in adults without altered systemic immunity

Tested variables Treated patients (n=25) Untreated patients (n=26)   P-value OR [95% CI]
Clinical criteria
 BMI < 18 (kg/m2) 13/24 (54.2) 5/23 (21.7)   0.026 4.25 [1.18-15.2]
 Weight loss > 5% 17 (68) 10 (38.5)   0.05 3.4 [1.07-10.77]
 fatigue 13 (52) 7 (27)   0.071 2.94 [0.9-9.46]
 chronic cough 16 (64) 14 (54)   0.572 1.52 [0.49-4.69]
 night sweats 5 (20) 3 (11.5)   0.465 1.92 [0.41-9.05]
 hemoptysis 8 (32) 1 (3.8)   0.026 11.8 [1.3-102.8]
Microbiological criteria
 AFB-positive sputum sample on direct examination 13 (52) 8 (30.8)   0.160 2.44 [0.77-7.65]
 NTM-positive culture NTM on lower respiratory tract sample 2 (1-2.3) 1 (1-1.8)   0.044 1.79 [1-3.2]
Functional criteria
 FEV1 (L) 1.6 (1.2-2.2) 1.9 (1.2-2.5)   0.554 0.72 [0.34-1.51]
Immunological and nutritional status
 total lymphocyte count (G/L) 1.3 (1.2-1.7) 1.4 (1.1-2.1)   0.388 0.95 [0.86-1.04]
 CD4+ lymphocyte count (%) 54 (4.5-61.5) 40 (37.8-44.3)   0.031 1.07 [0.95-1.21]
 serum albumin (mg/L) 39.5 (36-43) 39 (33-42.5)   0.481 1.05 [0.97-1.14]
 serum pre-albumin (mg/L) 0.21 (0.15-0.24) 0.22 (0.15-0.25)   0.974 1.25 [0-1.48]
 vitamin D deficiency 6/10 (60) 6/7 (86)   0.338 0.25 [0.02-2.95]
Co-infection(s)
Mycobacterium tuberculosis 1 (4) 1 (4)   0.35 1.04 [0.06-17.6]
Pseudomonas spp. 2 (8) 3 (11.5)   1 0.68 [0.1-4.4]
Aspergillus spp. 15 (60) 5 (19.2)   0.004 6.3 [1.8-22.2]
Radiologic features at diagnosis
 nodule(s) (≥ 10mm) 12 (48) 7/23 (30)   0.25 2.11 [0.65-6.9]
 cluster(s) of micronodules (< 5mm) 16 (64) 10/23 (44)   0.246 2.31 [0.72-7.4]
 cavitation(s) 18 (72) 8/23 (35)   0.019 4.82 [1.42-16.4]
 bronchiectasis 14 (56) 11/23 (48)   0.773 1.39 [0.45-4.3]
 emphysema 9 (36) 11/23 (48)   0.559 0.61 [0.19-1.95]
Radiologic review
 regression 8/23 (35) 4/13 (31)   1 1.2 [0.28-5.15]
 stabilization 9/23 (39) 6/13 (46)   0.736 0.75 [0.19-2.97]
 worsening 6/23 (26) 3/13 (23)   1 1.18 [0.24-5.8]
  1. NOTE Data are No. (%) of patients, unless otherwise indicated. Denominators have been stipulated for variables with missing data. Odds ratios (OR) were determined by conditional logistic regression with 95% confidence interval (95% CI)
  2. Abbreviations: AFB, acid-fast bacilli; BMI, body mass index; CI, confidence interval; FEV1, forced expiratory volume in 1 second; NTM, nontuberculous mycobacteria; OR, odds ratio