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Table 3 Factors associated with severe dengue

From: Dengue fever in Dar es Salaam, Tanzania: clinical features and outcome in populations of black and non-black racial category

  Severe dengue No severe dengue Univariate analysis P value Multivariate analysis P value
N = 20 N = 408 Unadjusted OR or coefficient (95% CI) Adjusted OR or coefficient (95% CI)
Age, years 36 (27–50) 35 (27–45) 1.0 (0.99–1.05) 0.21 0.98 (0.94–1.0) 0.41
Male sex 10 (50) 217 (53) 0.88 (0.36–2.2) 0.78   
Low socioeconomic status 5 (25) 173 (42) 0.45 (0.16–1.3) 0.13   
Black race 6 (30) 234 (57) 0.32 (0.12–0.85) 0.02 0.26 (0.09–0.77) 0.02
Private clinic 14 (70) 229 (56) 1.8 (0.69–4.8) 0.22   
Malaria coinfection 0 (0) 15 (3.7)     
Pregnancy 0 (0) 8 (2.0)     
History of diabetes 3 (15) 3 (0.74) 24 (4.5–127) < 0.001 43 (5.2–361) < 0.001
Secondary dengue 3 (15) 554 (13.2) 1.2 (0.33–4.1) 0.82 1.5 (0.40–5.4) 0.56
Warning signs 9 (45) 120 (29) 2.0 (0.79–4.9) 0.14   
 Abdominal pain 4 (20) 62 (15) 1.4 (0.45–4.3) 0.56   
 Persistent vomiting 4 (20) 36 (8.8) 2.6 (0.82–8.1) 0.1   
 Clinical fluid accumulation 1 (5) 3 (0.74) 7.1 (0.71–71.5) 0.1   
 Mucosal bleed 5 (25) 33 (8) 3.8)1.3–11) 0.02   
Laboratory parameters a
 Hematocrit, % 43 (41–46) 42 (38–46) 1.0 (0.95–1.1) 0.69   
 Hematocrit > 45% 7 (35) 113 (28) 1.4 (0.55–3.61) 0.48   
 Platelets, ×109/L 146 (103–186) 150 (116–189) 1.0 (0.99–1.0) 0.71   
 Platelets < 100 × 109/L 4 (20) 66 (16) 1.3 (0.42–4.0) 0.65   
 Leukocytes, ×109/L 9 (45) 134 (33) 0.99 (0.87–1.1) 0.83   
 Leukocytes < 3.5 × 109/L 9 (45) 134 (33) 1.7 (0.68–4.13) 0.27   
  1. aBlood count values missing in 18 patients