Age, years
|
35 (27–45)
|
30 (23–40)
|
41 (34–49)
|
< 0.001
|
Male sex
|
227 (53)
|
135 (56)
|
92 (49)
|
0.13
|
Low socioeconomic status
|
178 (42)
|
178 (74)
|
0 (0)
|
< 0.001
|
Malaria coinfection
|
15 (3.5)
|
12 (5.0)
|
3 (1.6)
|
0.06
|
Pregnancy
|
8 (1.9)
|
5 (2.1)
|
3 (1.6)
|
0.71
|
HIV a
|
11 (2.6)
|
11 (4.6)
|
0 (0)
|
NA
|
History of diabetes
|
6 (1.4)
|
3 (1.3)
|
3 (1.6)
|
0.76
|
Secondary dengue
|
57 (13.3)
|
31 (13)
|
26 (14)
|
0.78
|
Symptoms and signs at inclusion
|
Duration of symptoms, days; Mean (SD)
|
2.8 (1.4)
|
2.9 (1.3)
|
2.7 (1.6)
|
0.01
|
Headache
|
374 (87)
|
220 (92)
|
154 (82)
|
0.003
|
Rash
|
98 (23)
|
10 (4.2)
|
88 (47)
|
< 0.001
|
Myalgia/Arthralgia
|
286 (67)
|
182 (76)
|
104 (55)
|
< 0.001
|
Vomiting
|
87 (20)
|
47 (20)
|
40 (21)
|
0.67
|
Systolic blood pressure < 90mmh b
|
10 (2.3)
|
1 (0.4)
|
9 (4.8)
|
0.003
|
Pulse pressure ≤ 20 mmHg b
|
7 (1.6)
|
2 (0.8)
|
5 (2.7)
|
0.14
|
Altered mental status; Glasgow Coma Score < 15
|
2 (0.5)
|
2 (0.8)
|
0 (0)
|
0.21
|
Warning signs at inclusion and within 7 days of follow-up
|
129 (30)
|
67 (28)
|
62 (33)
|
0.26
|
Abdominal pain
|
66 (15.4)
|
40 (17)
|
26 (14)
|
0.42
|
Persistent vomiting
|
40 (9.4)
|
23 (9.6)
|
17 (9.0)
|
0.85
|
Clinical fluid accumulation
|
4 (0.9)
|
2 (0.8)
|
2 (1.1)
|
0.81
|
Mucosal bleed
|
42 (9.7)
|
14 (5.8)
|
24 (13)
|
0.01
|
Laboratory parameters at inclusion c
|
Hemoglobin, mg/l
|
14 (13–15)
|
14 (13–15)
|
14 (12–15)
|
0.48
|
Hematocrit, %
|
42 (39–46)
|
42 (38–46)
|
43 (40–46)
|
0.005
|
Hematocrit > 45%
|
120 (28)
|
54 (23)
|
66 (35)
|
0.004
|
Leukocytes, ×109/L
|
4.5 (3.1–6.0)
|
4.6 (3.1–6.2)
|
4.2 (3.0–5.6)
|
0.16
|
Leukocytes < 3.5x109G/L
|
143 (33)
|
76 (32)
|
67 (36)
|
0.39
|
Platelets, ×109/L
|
150 (115–189)
|
147 (106–195)
|
11 (122–178)
|
0.82
|
Platelets < 100 × 109/L
|
70 (16)
|
48 (20)
|
22 (12)
|
0.02
|
Clinical outcome at day 7
|
Severe dengue d
|
20 (4.7)
|
6 (2.5)
|
14 (7.5)
|
0.02
|
Death
|
2 (0.5)
|
2 (0.8)
|
0 (0)
|
0.21
|
Admission
|
39 (9.1)
|
21 (8.8)
|
18 (9.6)
|
0.77
|
Intravenous fluid
|
55 (13)
|
18 (7.5)
|
37 (20)
|
< 0.001
|