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Table 2 Summary of specific outcomes of hospital acquired infections among adults admitted to intensive care, from randomised controlled trials

From: Evidence for the effectiveness of chlorhexidine bathing and health care-associated infections among adult intensive care patients: a trial sequential meta-analysis

Outcome of interest no. of trials [ref] (no. of patients) Summary estimate,
Risk Ratio (95% CI)
[test of heterogeneity, p-value]
Baseline risk
(among control period)
Estimated information
size1
BSI 4-trials [6, 21, 30]
(n = 18,290)
MH (FE) RR = 0.75 (0.63, 0.91)
[I2 = 49%, het test, p = 0.117]
6 / 1000 ICU days 62,700 (HIS)
CLABSI 3-trials [6, 21, 28]
(n = 17,540)
MH (FE) RR = 0.56 (0.35, 0.89)
[I2 = 9%, het test, p = 0.331
3 / 1000 lines days 62,700 (HIS)
MRDO 2-trials [6, 21]
(n = 17,152)
MH (FE) RR = 0.82 (0.69, 0.98)
[I2 = 0%, het test, p-value = 0.416]
6 / 1000 ICU days 34,000 (IS)
VAP 3-trials [21, 30]
(n = 10,564)
MH (FE) RR = 1.55 (0.79, 3.01)
[I2 = 17%, het test, p-value = 0.213]
5 / 1000 MV days 40,950 (HIS)
CAUTI 3-trials [21, 28, 29]
(n = 9983)
MH (FE) RR = 0.77 (0.52, 1.14)
[I2 = 0%, het test, p-value = 0.539)
6 / 1000 catheter days 32,000 (IS)
  1. Note: BSI Blood Stream Infection, CLABSI Central Line Associated Blood Stream Infection, MDRO Multi-Drug Resistant Organism, VAP Ventilator Associated Pneumonia, and CAUTI Catheter Associated Urinary Tract Infections, CI confidence interval, MH Cochrane-Mantel-Haenszel, FE Fixed Effect. Heterogeneity Information size estimated using the approach suggested by Thorlund et al [14]. HIS Heterogeneity adjusted Information Size (I2 < 0%), IS (Information Size, I2 > 0%)