Table 2 GRADE quality assessment of direct evidence of each pairwise treatment comparison for treatment success
Treatment comparison | Number of head-to head trials(n) | Study limitations` | Precision | Consistency | Directness | Publication bias | Direct Estimate; OR (95% CI) | Absolute effect per 100 treated (95% CI) | Overall quality of evidence |
|---|---|---|---|---|---|---|---|---|---|
LMV vs TDF plus LMV | 4 (158) | seriousa | very seriousb | very serious (I2: 62%)c | serious | likely to exist | 0.37 (0.06–2.41) | 218 fewer (from 121 more to 602 fewer) | very low ⊕◯◯◯ |
FTC vs TDF | 1 (15) | seriousa | very seriousa | not serious | not serious | likely to exist | 0.07 (0.00–1.14) | 513 fewer (0 to 11 more) | very low ⊕◯◯◯ |
LMV vs TDF | 2 (84) | seriousa | very seriousa | very seriousc(I2: 78%) | serious | likely to exist | 0.12 (0.00–5.71) | 27 fewer (87 fewer to 141 more) | very low ⊕◯◯◯ |
LMV vs placebo | 2 (130) | seriousa | very seriousa | not serious (I2: 0%) | serious | likely to exist | 0.73 (0.2–2.69) | 432 fewer (0 to 109 more) | very low ⊕◯◯◯ |
TDF vs TDF plus LMV | 2 (37) | seriousa | very seriousa | very seriousc(I2: 51%) | serious | likely to exist | 1.21 (0.06–23.06) | 21 more (127 more to 586 fewer) | very low ⊕◯◯◯ |
TDF vs placebo | 1 (12) | seriousa | very seriousb | not serious | not serious | likely to exist | 105.00(1.65–6697.38) | 0 fewer (0 fewer to 0 fewer) | very low ⊕◯◯◯ |
TDF plus LMV vs placebo | 1 (15) | seriousa | very seriousb | not serious | not serious | likely to exist | 7.00 (0.24–206.78) | 239 more (294 more to 341 fewer) | very low ⊕◯◯◯ |
ADV vs TDF | 1 (52) | seriousa | very seriousb | not serious | not serious | likely to exist | 3.23 (0.85–12.35) | 212 more (19 fewer to 534 more) | very low ⊕◯◯◯ |