Table 1 Clinical characteristics of neonates with and without persistent candidemia
From: Persistent candidemia in very low birth weight neonates: risk factors and clinical significance
Variable | Persistent candidemia | P value | Odds ratio (OR) (95% CI) | |
|---|---|---|---|---|
Yes mean (95% CI) or n (%) | No mean (95% CI) or n (%) | |||
Demographics | ||||
Gestational age (wks) | 29.6 (27.3, 31.9) | 29.7 (28.1, 31.2) | 0.766 | |
Birth weight (g) | 1097.8 (866.4,1309.2) | 1229.0 (1051.1,1046.9) | 0.029 | |
Male gender, n (%) | 12 (42.9) | 5 (25.0) | 0.207 | 0.44 (0.13–1.57) |
Admission age | 1.3 (0.4, 2.2) | 1.8 (2.4, 6.0) | 0.611 | |
Risk factors | ||||
Necrotizing enterocolitis | 9 (32.1) | 1 (5.0) | 0.046 | 9.0 (1.04–78.17) |
Neurodevelopmental impairment | 6 (21.4) | 6 (30.0) | 0.501 | 0.64 (0.17–2.37) |
Vaginal delivery | 13 (46.4) | 7 (35.0) | 0.430 | 1.61 (0.49–5.25) |
Fetal membrane rupture (h) | 46.4 (25.1, 117.7) | 18.8 (37.5, 75.1) | 0.143 | |
Congentital diseases | 15 (53.6) | 10 (50.0) | 0.867 | 1.15 (0.37–3.64) |
Abdominal surgery | 3 (10.7) | 0 (0.0) | – | – |
Mechanical ventilation | 24 (85.7) | 10 (50.0) | 0.011 | 6.00 (1.52–23.70) |
Central venous catheter | 15 (59.6) | 13 (65.0) | 0.430 | 0.62 (0.19–2.03) |
Intubation | 20 (71.4) | 3 (15.0) | 0.000 | 14.17 (3.24–61.99) |
Total parenteral nutrition | 26 (92.9) | 19 (95.0) | 0.764 | 0.68 (0.06–8.11) |
Hospitalization duration (d) | 58.8 (33.8, 93.8) | 49.3 (32.4, 66.2) | 0.147 | |
3rdcephalosporins use | 16 (59.3) | 13 (65.0) | 0.689 | 0.78 (0.24–2.59) |
Carbapenems use | 26 (92.9) | 16 (80.0) | 0.201 | 3.25 (0.53–19.82) |
Vancomycin use | 7 (25.0) | 2 (10.0) | 0.203 | 3.00 (0.55–16.31) |
Multiple antibiotic use | 18 (64.3) | 13 (65.0) | 0.959 | 0.97 (0.29–3.22) |
Antibiotic therapeutic duration (d) | 44.5 (24.3, 64.7) | 31.1 (16.6, 55.6) | 0.015 | |
Non-C.albicans | 21 (75.0) | 8 (40.0) | 0.017 | 4.50 (1.31–15.52) |
Prophylaxis antifungal therapy | 25 (89.3) | 16 (80.0) | 0.375 | 2.08 (0.41–10.56) |
Antifungal therapeutic duration (d) | 11.3 (4.6, 18.0) | 9.2 (4.6, 14.4) | 0.243 | |
Outcome | ||||
Death | 4 (14.3) | 1 (5.0) | 0.320 | 3.17 (10.33–30.73) |