Table 3 Clinical characteristics of the 8 cases of NVP-induced liver injury. *HLAB5701 tested absent
| Â | Pt 1 | Pt 2 | Pt 3 | Pt 4 | Pt 5 | Pt 6 | Pt 7 | Pt 8 |
|---|---|---|---|---|---|---|---|---|
HCV coinfection | no | yes | yes | yes | yes | no | yes | yes |
ARV status | Experienced | Experienced | Experienced | Experienced | Naive | Experienced | Experienced | Experienced |
Concomitant ARV | d4T + 3TC | d4T + 3TC | ABC* + 3TC | AZT + 3TC | AZT + 3TC | d4T + ddi | AZT + 3TC | d4T + ddi |
NVP exposure before treatment interruption (days) | 28 | 61 | 29 | 28 | 58 | 28 | 50 | 38 |
Concomitant medication | none | none | Vitamin D and folinic acid | none | Phenobarbital and alprazolam | none | None | Folinic acid |
Symptoms | Nausea and severe weakness | none | Nausea | none | Weakness | none | Nausea | None |
Required hospitalization | yes | no | yes | no | no | no | no | no |
Outcome | Recovered without sequelae | Recovered without sequelae | Recovered without sequelae | Recovered without sequelae | Recovered without sequelae | Recovered without sequelae | Recovered without sequelae | Recovered without sequelae |
RUCAM | Probable | Probable | Possible | Probable | Possible | Probable | Probable | Possible |