Table 3 Parameters at baseline and during follow-up
Parameters | Group A baseline mean (SD) | Month 1 mean (SD) | End of treatment mean (SD) | 6th month of follow-up mean (SD) | p-value* | Group B baseline mean (SD) | Month 1 mean (SD) | End of treatment mean (SD) | 6th month of follow-up mean (SD) | p-value* |
|---|---|---|---|---|---|---|---|---|---|---|
FIB-4 | 3.8 (3.6) | – | – | 2.7 (1.8) | 0.003 | 5.5 (5.3) | – | – | 3.7 (4.7) | < 0.001 |
APRI SCORE | 1.2 (1.1) | – | – | 0.6 (0.9) | < 0.001 | 1.7 (1.8) | – | – | 0.9 (2.1) | 0.002 |
INR | 1.1 (0.2) | – | – | 1.1 (0.1) | 0.111 | 1.1 (0.2) | – | – | 1.1 (0.1) | 0.435 |
α-fetoprotein (ng/mL) | 12.8 (20.9) | – | – | 7.8 (19.3) | < 0.001 | 19.5 (28.9) | – | – | 5.9 (3.1) | 0.014 |
Creatinine (mg/dL) | 0.8 (0.2) | – | – | 0.9 (0.2) | 0.031 | 0.7 (0.1) | – | – | 0.8 (0.1) | 0.032 |
Glucose (mg/dL) | 112 (29) | – | – | 110.5 (30.8) | 0.266 | 128.6 (41.7) | – | – | 119.3 (31.7) | 0.337 |
Haemoglobin (g/dL) | 14.2 (2.2) | – | – | 14.1 (2.1) | 0.551 | 13.6 (1.9) | – | – | 13.9 (1.8) | 0.625 |
Cholesterol (mg/dL) | 155.2 (30.8) | – | – | 163.5 (29.8) | 0.070 | 149.9 (38.1) | – | – | 179.3 (46.2) | 0.003 |
Triglycerides (mg/dL) | 111.25 (46.12) | – | – | 110.96 (46.49) | 0.155 | 112.12 (39.64) | – | – | 100.8 (46.73) | 0.295 |
AST (UI/L) | 59.2 (40.9) | 24.8 (13.3) | 22.9 (9.1) | 25.6 (13.4) | < 0.001 | 68.7 (40.6) | 29.8 (19.7) | 23.8 (8.3) | 24.3 (8.3) | < 0.001 |
ALT (UI/L) | 65. (41.3) | 21.7 (11.4) | 18.3 (6.8) | 20.5 (9.4) | < 0.001 | 69.7 (52.3) | 24 (15.1) | 20.5 (8.5) | 20.3 (10) | < 0.001 |
Platelet (×10 [3]/mL) | 166.8 (65.8) | 183.4 (78.5) | 171.1 (77.5) | 167.1 (61.5) | 0.399 | 139.3 (62.1) | 161.2 (72.3) | 153.9 (65.4) | 150.2 (58.9) | 0.779 |
Total bilirubin (mg/dL) | 0.9 (0.7) | 1.1 (0.7) | 0.9 (0.8) | 0.7 (0.5) | < 0.001 | 1 (0.8) | 1 (0.7) | 0.7 (0.6) | 0.8 (0.5) | < 0.001 |
Ejection Fraction (%) | 56.5 (3.1) | 56.9 (3.5) | 56.6 (2.5) | 56.7 (2.8) | 0.499 | 56.9 (2.9) | 57 (3) | 57.2 (3.2) | 57.4 (3.6) | 0.535 |
GLS (%) | −20.8 (2.8) | −21.4 (2.4) | −20.9 (2.6) | −20.3 (2.6) | 0.031 | −21.1 (2.4) | −20.7 (2.7) | −20.3 (2.8) | −20.1 (2.5) | 0.097 |