Skip to main content

Table 3 Parameters at baseline and during follow-up

From: Evaluation of cardiac function by global longitudinal strain before and after treatment with sofosbuvir-based regimens in HCV infected patients

Parameters Group A
baseline mean (SD)
Month 1 mean (SD) End of treatment mean (SD) 6th month of follow-up mean (SD) p-value* Group B
baseline mean (SD)
Month 1 mean (SD) End of treatment mean (SD) 6th month of follow-up mean (SD) p-value*
FIB-4 3.8 (3.6) 2.7 (1.8) 0.003 5.5 (5.3) 3.7 (4.7) < 0.001
APRI SCORE 1.2 (1.1) 0.6 (0.9) < 0.001 1.7 (1.8) 0.9 (2.1) 0.002
INR 1.1 (0.2) 1.1 (0.1) 0.111 1.1 (0.2) 1.1 (0.1) 0.435
α-fetoprotein (ng/mL) 12.8 (20.9) 7.8 (19.3) < 0.001 19.5 (28.9) 5.9 (3.1) 0.014
Creatinine (mg/dL) 0.8 (0.2) 0.9 (0.2) 0.031 0.7 (0.1) 0.8 (0.1) 0.032
Glucose (mg/dL) 112 (29) 110.5 (30.8) 0.266 128.6 (41.7) 119.3 (31.7) 0.337
Haemoglobin (g/dL) 14.2 (2.2) 14.1 (2.1) 0.551 13.6 (1.9) 13.9 (1.8) 0.625
Cholesterol (mg/dL) 155.2 (30.8) 163.5 (29.8) 0.070 149.9 (38.1) 179.3 (46.2) 0.003
Triglycerides (mg/dL) 111.25 (46.12) 110.96 (46.49) 0.155 112.12 (39.64) 100.8 (46.73) 0.295
AST (UI/L) 59.2 (40.9) 24.8 (13.3) 22.9 (9.1) 25.6 (13.4) < 0.001 68.7 (40.6) 29.8 (19.7) 23.8 (8.3) 24.3 (8.3) < 0.001
ALT (UI/L) 65. (41.3) 21.7 (11.4) 18.3 (6.8) 20.5 (9.4) < 0.001 69.7 (52.3) 24 (15.1) 20.5 (8.5) 20.3 (10) < 0.001
Platelet (×10 [3]/mL) 166.8 (65.8) 183.4 (78.5) 171.1 (77.5) 167.1 (61.5) 0.399 139.3 (62.1) 161.2 (72.3) 153.9 (65.4) 150.2 (58.9) 0.779
Total bilirubin (mg/dL) 0.9 (0.7) 1.1 (0.7) 0.9 (0.8) 0.7 (0.5) < 0.001 1 (0.8) 1 (0.7) 0.7 (0.6) 0.8 (0.5) < 0.001
Ejection Fraction (%) 56.5 (3.1) 56.9 (3.5) 56.6 (2.5) 56.7 (2.8) 0.499 56.9 (2.9) 57 (3) 57.2 (3.2) 57.4 (3.6) 0.535
GLS (%) −20.8 (2.8) −21.4 (2.4) −20.9 (2.6) −20.3 (2.6) 0.031 −21.1 (2.4) −20.7 (2.7) −20.3 (2.8) −20.1 (2.5) 0.097
  1. We compared baseline and 6th month of follow-up values of the two groups of treatment (group A = 3 months of treatment, group B = 6 months of treatment) with t-test for FIB-4, APRI SCORE, α-fetoprotein, creatinine, glucose, haemoglobin, cholesterol, and triglycerides. We use mixed-linear models to evaluate the linear trend of the other parameters
  2. --: the parameter is not available at this follow-up point