Oseltamivir in pregnancy and birth outcomes

BMC Infectious Diseases

Table 4 Prenatal exposure to oseltamivir and SGA, preterm birth, low 5-min Apgar score, and stillbirth

	Unexposed	Exposed	Crude odds ratio (95% CI)	Conventional regression analysis, odds ratio (95% CI)	Propensity score-matched regression analysis, odds ratio (95% CI)^c
First trimester
Number	670,602	406
Small for gestational age	64,944 (9.7%)	32 (7.9%)	0.80 (0.56 to 1.14)	0.88 (0.61 to 1.26)	0.75 (0.46 to 1.24)
Preterm birth	42,399 (6.3%)	28 (6.9%)	1.10 (0.75 to 1.61)	1.21 (0.83 to 1.79)	0.87 (0.52 to 1.46)
Low 5-min Apgar score^a	5429 (0.8%)	5 (1.2%)	1.52 (0.63 to 3.68)	1.64 (0.68 to 3.97)	1.00 (0.29 to 3.45)
Second/third trimester
Number	670,602	1449
Small for gestational age	64,944 (9.7%)	121 (8.3%)	0.85 (0.71 to 1.02)	0.94 (0.77 to 1.13)	0.84 (0.64 to 1.10)
Preterm birth	42,399 (6.3%)	79 (5.4%)	0.85 (0.68 to 1.07)	0.89 (0.70 to 1.12)	0.85 (0.62 to 1.16)
Low 5-min Apgar score^a	5429 (0.8%)	10 (0.7%)	0.85 (0.46 to 1.59)	0.92 (0.49 to 1.71)	1.25 (0.49 to 3.17)
Stillbirth^b	3047 (0.4%)	7 (0.5%)	1.06 (0.51 to 2.24)	1.13 (0.50 to 2.52)	1.20 (0.37 to 3.93)

Data are n (%) or odds ratio (95% CI) unless otherwise specified
SGA small for gestational age, CI confidence interval
^aLive born only
^bLive or stillborn at ≥22 weeks of gestation; data not shown for first-trimester exposure because of low counts
^cVariables included in estimation of propensity scores are listed in the Additional file 1

ISSN: 1471-2334