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Table 4 Prenatal exposure to oseltamivir and SGA, preterm birth, low 5-min Apgar score, and stillbirth

From: Oseltamivir in pregnancy and birth outcomes

  Unexposed Exposed Crude odds ratio (95% CI) Conventional regression analysis, odds ratio (95% CI) Propensity score-matched regression analysis, odds ratio (95% CI)c
First trimester
 Number 670,602 406    
 Small for gestational age 64,944 (9.7%) 32 (7.9%) 0.80 (0.56 to 1.14) 0.88 (0.61 to 1.26) 0.75 (0.46 to 1.24)
 Preterm birth 42,399 (6.3%) 28 (6.9%) 1.10 (0.75 to 1.61) 1.21 (0.83 to 1.79) 0.87 (0.52 to 1.46)
 Low 5-min Apgar scorea 5429 (0.8%) 5 (1.2%) 1.52 (0.63 to 3.68) 1.64 (0.68 to 3.97) 1.00 (0.29 to 3.45)
Second/third trimester
 Number 670,602 1449    
 Small for gestational age 64,944 (9.7%) 121 (8.3%) 0.85 (0.71 to 1.02) 0.94 (0.77 to 1.13) 0.84 (0.64 to 1.10)
 Preterm birth 42,399 (6.3%) 79 (5.4%) 0.85 (0.68 to 1.07) 0.89 (0.70 to 1.12) 0.85 (0.62 to 1.16)
 Low 5-min Apgar scorea 5429 (0.8%) 10 (0.7%) 0.85 (0.46 to 1.59) 0.92 (0.49 to 1.71) 1.25 (0.49 to 3.17)
 Stillbirthb 3047 (0.4%) 7 (0.5%) 1.06 (0.51 to 2.24) 1.13 (0.50 to 2.52) 1.20 (0.37 to 3.93)
  1. Data are n (%) or odds ratio (95% CI) unless otherwise specified
  2. SGA small for gestational age, CI confidence interval
  3. aLive born only
  4. bLive or stillborn at ≥22 weeks of gestation; data not shown for first-trimester exposure because of low counts
  5. cVariables included in estimation of propensity scores are listed in the Additional file 1