|
Number
|
670,602
|
406
|
1449
|
397
|
397
|
1420
|
1420
|
|
Age at conception (years)
|
|
< 20
|
14,636 (2.2)
|
11 (2.7)
|
32 (2.2)
|
6 (1.5)
|
11 (2.8)
|
23 (1.6)
|
31 (2.2)
|
|
20-35
|
549,563 (82.0)
|
310 (76.4)
|
1114 (76.9)
|
301 (75.8)
|
303 (76.3)
|
1109 (78.1)
|
1088 (76.6)
|
|
≥ 35
|
106,403 (15.9)
|
85 (20.9)
|
303 (20.9)
|
90 (22.7)
|
83 (20.9)
|
288 (20.3)
|
301 (21.2)
|
|
Age at conception (years)
|
|
Median (IQR)
|
30 (26–33)
|
30 (27–34)
|
30 (27–34)
|
31 (27–34)
|
30 (27–34)
|
31 (27–34)
|
30 (27–34)
|
|
Mean (SD)
|
30.0 (4.9)
|
30.7 (5.0)
|
30.8 (4.9)
|
31.1 (4.9)
|
30.8 (5.0)
|
31.0 (4.8)
|
30.8 (4.9)
|
|
Calendar year of conception
|
|
2002-2008
|
426,697 (63.6)
|
18 (4.4)
|
60 (4.1)
|
241 (60.7)
|
18 (4.5)
|
845 (59.5)
|
60 (4.2)
|
|
2009-2010
|
118,496 (17.7)
|
376 (92.6)
|
1335 (92.1)
|
78 (19.6)
|
367 (92.4)
|
265 (18.7)
|
1310 (92.3)
|
|
2011-2013
|
125,409 (18.7)
|
12 (3.0)
|
54 (3.7)
|
78 (19.6)
|
12 (3.0)
|
310 (21.8)
|
50 (3.5)
|
|
Unmarried
|
357,106 (53.3)
|
191 (47.0)
|
663 (45.8)
|
184 (46.3)
|
185 (46.6)
|
623 (43.9)
|
645 (45.4)
|
|
Pre-pregnancy body mass index (kg/m2)
|
|
< 18.5
|
24,336 (3.6)
|
20 (4.9)
|
46 (3.2)
|
6 (1.5)
|
20 (5.0)
|
55 (3.9)
|
46 (3.2)
|
|
18.5- < 25.0
|
355,498 (53.0)
|
238 (58.6)
|
835 (57.6)
|
204 (51.4)
|
233 (58.7)
|
766 (53.9)
|
822 (57.9)
|
|
25.0- < 30.0
|
118,521 (17.7)
|
84 (20.7)
|
305 (21.0)
|
75 (18.9)
|
83 (20.9)
|
269 (18.9)
|
300 (21.1)
|
|
≥ 30
|
70,259 (10.5)
|
54 (13.3)
|
212 (14.6)
|
48 (12.1)
|
52 (13.1)
|
166 (11.7)
|
206 (14.5)
|
|
Missing
|
101,988 (15.2)
|
10 (2.5)
|
51 (3.5)
|
64 (16.1)
|
9 (2.3)
|
164 (11.5)
|
46 (3.2)
|
|
Smoking
|
|
No
|
561,830 (83.8)
|
351 (86.5)
|
1258 (86.8)
|
358 (90.2)
|
351 (88.4)
|
1275 (89.8)
|
1258 (88.6)
|
|
Yes
|
95,528 (14.2)
|
46 (11.3)
|
162 (11.2)
|
39 (9.8)
|
46 (11.6)
|
145 (10.2)
|
162 (11.4)
|
|
Missinga
|
13,244 (2.0)
|
9 (2.2)
|
29 (2.0)
|
–
|
–
|
–
|
–
|
|
Parity
|
|
0
|
314,229 (46.9)
|
136 (33.5)
|
441 (30.4)
|
122 (30.7)
|
132 (33.2)
|
415 (29.2)
|
427 (30.1)
|
|
1
|
242,531 (36.2)
|
183 (45.1)
|
637 (44.0)
|
187 (47.1)
|
179 (45.1)
|
654 (46.1)
|
627 (44.2)
|
|
2
|
86,863 (13.0)
|
64 (15.8)
|
296 (20.4)
|
67 (16.9)
|
63 (15.9)
|
270 (19.0)
|
292 (20.6)
|
|
> 2
|
26,979 (4.0)
|
23 (5.7)
|
75 (5.2)
|
21 (5.3)
|
23 (5.8)
|
81 (5.7)
|
74 (5.2)
|
|
Prior delivery of a child with a malformation (since 1994)
|
20,171 (3.0)
|
16 (3.9)
|
67 (4.6)
|
19 (4.8)
|
16 (4.0)
|
72 (5.1)
|
64 (4.5)
|
|
Hospital history during 12 months before conceptionb
|
|
At least one inpatient hospitalization
|
124,627 (18.6)
|
83 (20.4)
|
334 (23.1)
|
75 (18.9)
|
79 (19.9)
|
270 (19.0)
|
327 (23.0)
|
|
At least one visit to outpatient specialist clinic
|
232,129 (34.6)
|
169 (41.6)
|
609 (42.0)
|
155 (39.0)
|
165 (41.6)
|
570 (40.1)
|
597 (42.0)
|
|
At least one emergency room visit
|
85,760 (12.8)
|
80 (19.7)
|
215 (14.8)
|
69 (17.4)
|
77 (19.4)
|
180 (12.7)
|
211 (14.9)
|
|
Respiratory diseases
|
33,405 (5.0)
|
39 (9.6)
|
90 (6.2)
|
38 (9.6)
|
39 (9.8)
|
89 (6.3)
|
89 (6.3)
|
|
Cardiovascular disease
|
7760 (1.2)
|
7 (1.7)
|
30 (2.1)
|
5 (1.3)
|
6 (1.5)
|
15 (1.1)
|
29 (2.0)
|
|
Haematological disease
|
2364 (0.4)
|
5 (1.2)
|
15 (1.0)
|
0 (0.0)
|
5 (1.3)
|
8 (0.6)
|
15 (1.1)
|
|
Diabetes
|
10,590 (1.6)
|
5 (1.2)
|
38 (2.6)
|
7 (1.8)
|
5 (1.3)
|
29 (2.0)
|
37 (2.6)
|
|
Neurological diseaseb
|
5654 (0.8)
|
5 (1.2)
|
20 (1.4)
|
–
|
–
|
–
|
–
|
|
Obesityc
|
73,216 (10.9)
|
56 (13.8)
|
222 (15.3)
|
49 (12.3)
|
54 (13.6)
|
174 (12.3)
|
216 (15.2)
|
|
Disorders of female pelvic organs/genital tract
|
44,730 (6.7)
|
32 (7.9)
|
86 (5.9)
|
25 (6.3)
|
32 (8.1)
|
70 (4.9)
|
84 (5.9)
|
|
Hospital contact for injury or poisoning
|
60,037 (9.0)
|
51 (12.6)
|
148 (10.2)
|
51 (12.8)
|
50 (12.6)
|
130 (9.2)
|
144 (10.1)
|
|
Use of prescription medication in the 12 months before conception
|
|
Antidepressants
|
34,293 (5.1)
|
30 (7.4)
|
115 (7.9)
|
29 (7.3)
|
29 (7.3)
|
105 (7.4)
|
109 (7.7)
|
|
Drugs for ulcer/gastroesophageal reflux
|
26,456 (3.9)
|
27 (6.7)
|
84 (5.8)
|
18 (4.5)
|
26 (6.5)
|
80 (5.6)
|
83 (5.8)
|
|
Oral contraceptives
|
243,936 (36.4)
|
156 (38.4)
|
534 (36.9)
|
173 (43.6)
|
153 (38.5)
|
517 (36.4)
|
523 (36.8)
|
|
Drugs for in-vitro fertilization
|
54,563 (8.1)
|
43 (10.6)
|
116 (8.0)
|
35 (8.8)
|
43 (10.8)
|
103 (7.3)
|
114 (8.0)
|
|
Thyroid hormones
|
7284 (1.1)
|
8 (2.0)
|
25 (1.7)
|
8 (2.0)
|
8 (2.0)
|
31 (2.2)
|
24 (1.7)
|
|
Systemic corticosteroids
|
13,005 (1.9)
|
17 (4.2)
|
49 (3.4)
|
17 (4.3)
|
16 (4.0)
|
41 (2.9)
|
49 (3.5)
|
|
Non-steroidal anti-inflammatory drugs
|
98,907 (14.7)
|
78 (19.2)
|
268 (18.5)
|
66 (16.6)
|
77 (19.4)
|
252 (17.7)
|
261 (18.4)
|
|
Opiates
|
21,777 (3.2)
|
18 (4.4)
|
58 (4.0)
|
17 (4.3)
|
17 (4.3)
|
76 (5.4)
|
57 (4.0)
|
|
Systemic anti-infective agents other than oseltamivir
|
278,680 (41.6)
|
195 (48.0)
|
734 (50.7)
|
189 (47.6)
|
190 (47.9)
|
740 (52.1)
|
719 (50.6)
|
|
Number of different drugs classes dispensed, median (IQR)
|
1 (1–2)
|
2 (1–3)
|
2 (1-3)
|
2 (1–3)
|
2 (1–3)
|
2 (1–3)
|
2 (1–3)
|
