Table 1 Documented exacerbations with Gram-negative organisms reported to be Burkholderia pseudomallei, Pseudomonas sp., Pseudomonas aeruginosa, or Burkholderia cepacia (December 2013 – February 2017)
Organism | Source / Date | Antibiotic susceptibility test | Other data | ||
|---|---|---|---|---|---|
Resistant | Intermediate | Sensitive | |||
Burkholderia pseudomallei | Sputum (December 2013) | • Amoxicilin-clavulanate |  | • Ceftazidime • Doxycycline • Imipenem • Co-timoxazole | *Pus cell: > 25/lpf *Epithelial cell: 3/lpf |
Burkholderia pseudomallei | Sputum (August 2014) |  |  | • Amoxicilin-clavulanate • Ceftazidime • Doxycycline • Imipenem • Co-timoxazole | *Pus cell: > 25/lpf *Epithelial cell: 5/lpf |
Pseudomonas | Sputum (August 2014) | • Gentamicin |  | • Ceftazidime • Piperacillin-tazobactam | *Pus cell: > 25/lpf *Epithelial cell: 15/lpf |
Burkholderia cepacia | Bronchoalveolar lavage (August 2015) | • Amoxicilin-clavulanate • Amikacin • Azithromycin • Ciprofloxacin • Gentamicin • Imipenem • Piperacillin-tazobactam |  | • Co-trimoxazole • Meropenem • Ceftazidime | *No virus detected *AFB weakly positive *No Mycobacterium |
Burkholderia cepacia | Sputum (November 2015) | • Imipenem • Co-trimoxazole |  | • Meropenem • Ceftazidime | *Pus cell: 0/lpf *Epithelial cell: 1/lpf *AFB negative |
Pseudomonas aeruginosa | Sputum (January 2016) | • Azithromycin |  | • Amikacin • Ceftazidime • Ciprofloxacin • Gentamicin • Meropenem | – |
Burkholderia pseudomallei | Sputum (March 2016) | • Co-trimoxazole |  |  | *Pus cell: 15/lpf *Epithelial cell: 0/lpf *AFB positive |
Burkholderia pseudomallei | Sputum (April 2016) | • Co-trimoxazole |  |  | *AFB positive |
Burkholderia pseudomallei | Sputum (May 2016) |  | • Doxycycline | • Ceftazidime • Imipenem Amoxicilin-clavulanate | *AFB positive *Acute duodenitis *No malignancy *Neutrophilic infiltration *OGDS - Pangastritis *Rapid urease test negative |
Burkholderia pseudomallei | Sputum (May 2016) | • Co-trimoxazole |  | • Amoxicillin-clavulanate |  |
Burkholderia pseudomallei | Sputum (May 2016) |  |  | • Sensitive to all antibiotics |  |
Burkholderia pseudomallei | Sputum (June 2016) |  |  | • Amoxicillin-clavulanate • Doxycycline | *AFB positive |
Burkholderia cepacia | Sputum (December 2016) | • Ciprofloxacin • Imipenem • Co-trimoxazole |  | • Ceftazidime • Meropenem |  |
Burkholderia pseudomallei | Bronchoalveolar lavage (February 2017) |  |  |  | *Candida parapsilosis (104–105) *AFB negative |
Burkholderia pseudomallei | Sputum (February 2017) | • Doxyccyline • Co-trimoxazole |  | • Amoxi-clavunate • Ceftazidime • Imipenem |  |