Table 1 Documented exacerbations with Gram-negative organisms reported to be Burkholderia pseudomallei, Pseudomonas sp., Pseudomonas aeruginosa, or Burkholderia cepacia (December 2013 – February 2017)
| Organism | Source / Date | Antibiotic susceptibility test | Other data | ||
|---|---|---|---|---|---|
| Resistant | Intermediate | Sensitive | |||
| Burkholderia pseudomallei | Sputum (December 2013) | • Amoxicilin-clavulanate |
• Ceftazidime • Doxycycline • Imipenem • Co-timoxazole |
*Pus cell: > 25/lpf *Epithelial cell: 3/lpf | |
| Burkholderia pseudomallei | Sputum (August 2014) |
• Amoxicilin-clavulanate • Ceftazidime • Doxycycline • Imipenem • Co-timoxazole |
*Pus cell: > 25/lpf *Epithelial cell: 5/lpf | ||
| Pseudomonas | Sputum (August 2014) | • Gentamicin |
• Ceftazidime • Piperacillin-tazobactam |
*Pus cell: > 25/lpf *Epithelial cell: 15/lpf | |
| Burkholderia cepacia | Bronchoalveolar lavage (August 2015) |
• Amoxicilin-clavulanate • Amikacin • Azithromycin • Ciprofloxacin • Gentamicin • Imipenem • Piperacillin-tazobactam |
• Co-trimoxazole • Meropenem • Ceftazidime |
*No virus detected *AFB weakly positive *No Mycobacterium | |
| Burkholderia cepacia | Sputum (November 2015) |
• Imipenem • Co-trimoxazole |
• Meropenem • Ceftazidime |
*Pus cell: 0/lpf *Epithelial cell: 1/lpf *AFB negative | |
| Pseudomonas aeruginosa | Sputum (January 2016) | • Azithromycin |
• Amikacin • Ceftazidime • Ciprofloxacin • Gentamicin • Meropenem | – | |
| Burkholderia pseudomallei | Sputum (March 2016) | • Co-trimoxazole |
*Pus cell: 15/lpf *Epithelial cell: 0/lpf *AFB positive | ||
| Burkholderia pseudomallei | Sputum (April 2016) | • Co-trimoxazole | *AFB positive | ||
| Burkholderia pseudomallei | Sputum (May 2016) | • Doxycycline |
• Ceftazidime • Imipenem Amoxicilin-clavulanate |
*AFB positive *Acute duodenitis *No malignancy *Neutrophilic infiltration *OGDS - Pangastritis *Rapid urease test negative | |
| Burkholderia pseudomallei | Sputum (May 2016) | • Co-trimoxazole | • Amoxicillin-clavulanate | ||
| Burkholderia pseudomallei | Sputum (May 2016) | • Sensitive to all antibiotics | |||
| Burkholderia pseudomallei | Sputum (June 2016) |
• Amoxicillin-clavulanate • Doxycycline | *AFB positive | ||
| Burkholderia cepacia | Sputum (December 2016) |
• Ciprofloxacin • Imipenem • Co-trimoxazole |
• Ceftazidime • Meropenem | ||
| Burkholderia pseudomallei | Bronchoalveolar lavage (February 2017) |
*Candida parapsilosis (104–105) *AFB negative | |||
| Burkholderia pseudomallei | Sputum (February 2017) |
• Doxyccyline • Co-trimoxazole |
• Amoxi-clavunate • Ceftazidime • Imipenem | ||