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Table 4 Summary of seven adults in whom HCV core antigen (HCV-Ag) assay was falsely negative, as compared to PCR for HCV RNA as a gold-standard reference test

From: Hepatitis virus (HCV) diagnosis and access to treatment in a UK cohort

Age group (years)

Sex

Patient location

Ethnicity

HIV status

HCV Ag (fmol/L)

HCV Ab

(sample/cut-off ratio)

Genotype

HCV viral load (IU/ml)

30–39

F

Sexual health

Unknown

negative

0.0

11.8

N/A

25

40–49

M

Primary care

European

negative

0.0

12.2

N/A

226

50–59

F

Hospital in-patient (General Medicine)

European

positive

0.0

3.1

N/A

302

20–29

M

Prison

European

negative

0.62

14.2

2b

2916

20–29

M

Prison

European

N/A

0.00

12.6

N/A

8232

30–39

F

Hospital out-patient

European

N/A

1.98

15.8

1b

13,860

30–39

M

Prison

European

negative

0.00

12.2

3a

174,834

  1. N/A = not available. Total number of HCV-Ag tests carried out in this period n = 305. None of the patients with a false negative result underwent a repeat Ag test so laboratory error cannot be ruled out in this instance. Threshold for positive HCV-Ag defined as ≥3 fmol/L. Samples are ranked in ascending viral load order