|
Drug susceptibility testing
|
total (n = 668)
|
Beijing family isolates(n = 558)
|
Non-Beijing family isolates (n = 110)
|
OR
|
95% CI
|
p-value
|
|---|
|
Pan sensitive
|
466
|
394
|
72
|
1.09
|
0.69–1.75
|
0.700
|
|
Any resistance to
|
|
Isoniazid
|
99
|
85
|
14
|
1.23
|
0.67–2.26
|
0.487
|
|
Rifampin
|
63
|
54
|
9
|
1.20
|
0.57–2.51
|
0.623
|
|
Ethambutol
|
42
|
38
|
4
|
1.56
|
0.54–4.50
|
0.415
|
|
Streptomycin
|
129
|
108
|
21
|
1.01
|
0.65–1.71
|
0.946
|
|
Kanamycin
|
28
|
20
|
8
|
2.11
|
0.90–4.92
|
0.078
|
|
ofloxacin
|
58
|
44
|
14
|
1.79
|
0.94–3.41
|
0.072
|
|
All four first-line drugs resistance
|
30
|
29
|
1
|
5.97
|
1.05–44.33
|
0.045
|
|
MDR-TB
|
50
|
47
|
3
|
3.28
|
1.01–10.37
|
0.038
|
|
Pre-XDR-TB
|
17
|
16
|
1
|
3.21
|
0.42–24.51
|
0.332
|
|
XDR-TB
|
11
|
10
|
1
|
1.99
|
0.25–15.69
|
1.001
|
- OR odds ratio, CI confidence interval
- MDR-TB: multi-drug resistance TB, resistant to at least isoniazid and rifampicin
- XDR-TB: extensively drug-resistant tuberculosis, MDR-TB plus resistance to ofloxacin and kanamycin
- Pre-XDR-TB: MDR-TB plus resistance to either ofloxacin or kanamycin
- First-line drugs resistance: resistant to isoniazid, rifampin, ethambutol and streptomycin
